Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

tpdA (P0C8P8) - Overview - Molecular Target Synopsis

Protein


tpdA, Thiostrepton
UniProt P0C8P8

Also Known as THCL_STRAJ, tpdA

Has bacteriocidal activity. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu).

6MXF
6 RESIDUE FRAGMENT OF
THIOSTREPTON
IN THE STRUCTURE OF
MICROED STRUCTURE OF THIOSTREPTON AT 1.9 A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for tpdA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
72P0C8P8-1

Sub-cellular localization


UniProt: tpdA is active in the following subcellular-locations: secreted.
GO terms: tpdA is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project tpdA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For tpdA there are:
10 structures (11 chains) solved
10 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis