Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSM4 (P0C7M7) - Overview - Molecular Target Synopsis

Protein


ACSM4, Acyl-coenzyme A synthetase ACSM4, mitochondrial
Enzyme Classification 6.2.1.2
UniProt P0C7M7

Also Known as ACSM4_HUMAN, ACSM4

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
580ENSG00000215009ENST00000399422ENSP00000382349P0C7M7-1

Sub-cellular localization


UniProt: ACSM4 is active in the following subcellular-locations: mitochondrion matrix.
GO terms: ACSM4 is active in the following subcellular-locations: mitochondrial matrix.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSM4 has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2171, NCI-H650, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ACSM4 there are:
7 structures (13 chains) solved
6 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

ACSM4 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (2VZE_A, 2VZE_B, 2VZE_C, 3EQ6_A, 3EQ6_B),
IBP/DEXIBUPROFEN (2WD9_A, 2WD9_B, 2WD9_C).

(see details)
Molecular Target 3D Synopsis