Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SBK3 (P0C264) - Overview - Molecular Target Synopsis

Protein


SBK3, Uncharacterized serine/threonine-protein kinase SBK3
Enzyme Classification 2.7.11.1
UniProt P0C264

Also Known as SBK3_HUMAN, SBK3, SGK110

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
423ENSG00000231274ENST00000420723ENSP00000388220
359P0C264-1
160ENSG00000231274ENST00000592464ENSP00000467263

Gene Copy Number Variation


In COSMIC - Cell Lines Project SBK3 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PSN1, PK-59, NCI-H727

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SBK3 has been screened with 87 compounds (94 bioactivities), 6 compounds have bioactivities that show binding affinity of <= 500nM (7 bioactivities). (see details)