Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SBK2 (P0C263) - Overview - Molecular Target Synopsis


SBK2, Serine/threonine-protein kinase SBK2
Enzyme Classification
UniProt P0C263

Also Known as SBK2_HUMAN, SBK2, SGK069

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
348ENSG00000187550ENST00000413299, ENST00000344158ENSP00000389015, ENSP00000345044P0C263-1

Sub-cellular localization

GO terms: SBK2 is active in the following subcellular-locations: cytoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SBK2 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2596, NCI-H2795, NCI-H226

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, NHLF

(see details)

Screening and Chemistry

SBK2 has been screened with compounds ( bioactivities). (see details)