Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SBK2 (P0C263) - Overview - Molecular Target Synopsis

Protein


SBK2, Serine/threonine-protein kinase SBK2
Enzyme Classification 2.7.11.1
UniProt P0C263

Also Known as SBK2_HUMAN, SBK2, SGK069

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
348ENSG00000187550ENST00000413299, ENST00000344158ENSP00000389015, ENSP00000345044P0C263-1

Sub-cellular localization


GO terms: SBK2 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SBK2 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2596, NCI-H2795, NCI-H226

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, NHLF

(see details)


Screening and Chemistry


SBK2 has been screened with compounds ( bioactivities). (see details)