Molecular Target Synopsis
Overview
Domains and Structures
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Chemistry
Ligand Efficiency Plot
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Gene Expression
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mscS (P0C0S1) - Overview - Molecular Target Synopsis

Protein


mscS, Small-conductance mechanosensitive channel
UniProt P0C0S1

Also Known as MSCS_ECOLI, mscS, yggB

Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds. Homoheptamer.

5AJI
MSCS D67R1 HIGH RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for mscS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: mscS is active in the following subcellular-locations: cell inner membrane.
GO terms: mscS is active in the following subcellular-locations: integral component of membrane, integral component of plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project mscS has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For mscS there are:
7 structures (49 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis