Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB40AL (P0C0E4) - Overview - Molecular Target Synopsis

Protein


RAB40AL, Ras-related protein Rab-40A-like
UniProt P0C0E4

Also Known as RB40L_HUMAN, RAB40AL, RLGP

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
300ENSG00000102128ENST00000218249ENSP00000218249
278P0C0E4-1

Sub-cellular localization


UniProt: RAB40AL is active in the following subcellular-locations: cytoplasm, membrane, mitochondrion.
GO terms: RAB40AL is active in the following subcellular-locations: cytoplasm, Golgi membrane, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB40AL has gain in 2 cell-lines, loss in 31 cell-lines and no signal in 972 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to RAB40AL there are:
105 structures (216 chains) solved
93 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB40AL is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB40AL has been screened with compounds ( bioactivities). (see details)