Molecular Target Synopsis
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rpsN (P0AG59) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed9
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria4


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2YKR_N 30S ribosomal protein S14 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.56 63.2 38.1 Yes No
2 empty 2 56.4 22.7 No No
3 empty 1.97 61.4 7.4 No No
4 empty 2.93 56.2 6.7 No No
5 empty 3.16 53.8 6 No No
6 empty 2.67 40 7.4 No No
7 empty 2.41 60.2 8.4 No No
8 empty 2.33 51.2 5 No No
5ME1_N 30S ribosomal protein S14 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.51 62.7 22.7 No No
2 empty 2.22 55 24.8 No No
3 empty 2.5 62.5 13.4 No No
4 empty 1.69 56 11.4 No No
5 empty 2.36 63.4 7.7 No No
6 empty 1.9 68.3 9 No No
7 empty 2.83 55.2 11.5 No No
8 empty 2.98 66.7 8.7 No No
9 empty 2.4 55.7 8.1 No No
10 empty 2.04 60.4 5.5 No No
4ADV_N 30S ribosomal protein S14 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 67.7 20.5 Yes Yes
2 empty 2.4 60.8 18.9 No No
3 empty 1.78 64.2 12.7 No No
4 empty 2.36 64.2 17.9 No No
5 empty 1.92 66.4 9.7 No No
6 empty 1.97 57 15.6 No No
7 empty 1.63 85.1 0 Yes No
8 empty 2.13 58.7 10.8 No No
9 empty 3.07 75.9 8 No No
10 empty 2.02 57.4 8.9 No No
5UZ4_N 30S ribosomal protein S14 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 63.2 38.3 Yes No
2 empty 2.32 61 22.1 No No
3 empty 1.92 60.6 12.5 No No
4 empty 2.2 65.3 9.9 No No
5 empty 2.47 60.9 9.3 No No
6 empty 2.09 77.6 9.4 No No
7 empty 2.19 59.3 7.3 No No
8 empty 2.26 78.3 8.1 No No
9 empty 2.17 54.2 9.2 No No
10 empty 2.09 54.3 6.9 No No
5NO3_N 30S ribosomal protein S14 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 65.1 19.7 No No
2 empty 2.32 57.5 23.6 No No
3 empty 1.99 54.9 23.6 No No
4 empty 2.77 58.1 13.8 No No
5 empty 2.05 55.9 12.1 No No
6 empty 2.29 62.2 10 No No
7 empty 1.9 51.1 12 No No
8 empty 2.59 59.1 12.9 No No
9 empty 2.36 64.1 7.5 No No
10 empty 3.11 69.9 7 No No
5ME0_N 30S ribosomal protein S14 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 63.2 23.6 No No
2 empty 1.79 56.5 17.8 No No
3 empty 2.51 58.2 21.1 No No
4 empty 2.46 61.7 12.5 No No
5 empty 2.55 57.6 13.6 No No
6 empty 1.64 57.5 13.1 No No
7 empty 2.94 68 8.9 No No
8 empty 2.13 64.9 8.1 No No
9 empty 2.41 60.9 8.1 No No
10 empty 2.71 53.1 12 No No
5MY1_N 30S ribosomal protein S14 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 64.7 19.8 No No
2 empty 1.95 63.8 18.6 No No
3 empty 2.4 63.7 19.1 No No
4 empty 2.43 65.8 16.9 No No
5 empty 2.04 65.3 10.4 No No
6 empty 1.76 85.4 0 Yes No
7 empty 2 55.7 15.7 No No
8 empty 2.21 58.4 10.5 No No
9 empty 3.15 69.5 8 No No
10 empty 2.33 50.3 9.9 No No
5NO4_N 30S ribosomal protein S14 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 61.7 17.3 No No
2 empty 2.28 59.2 23.2 No No
3 empty 2.05 55.2 21.3 No No
4 empty 2.24 60.9 22.3 No No
5 empty 2.69 55.6 14.9 No No
6 empty 2.1 63.3 16.5 No No
7 empty 2.57 56.5 12.5 No No
8 empty 2.89 68.1 11.2 No No
9 empty 2.5 63.3 7.4 No No
10 empty 2.92 69.6 6.3 No No
5NO2_N 30S ribosomal protein S14 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 66.3 18.6 No No
2 empty 2.4 58.7 23.7 No No
3 empty 1.95 54.1 23.8 No No
4 empty 2.61 54.9 14.3 No No
5 empty 2.09 61.8 18.7 No No
6 empty 2.31 61.8 10.6 No No
7 empty 2.54 59.5 12.8 No No
8 empty 2.66 65.6 11.3 No No
9 empty 1.79 53.8 11.4 No No
10 empty 3.03 67.1 10.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed47
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria36

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1VS5_N (144448) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.46Å No No
1VS7_N (144489) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.46Å Yes No
2AVY_N (144855) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.46Å No No
2AW7_N (144898) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.46Å Yes No
2I2P_N (145433) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.2Å Yes No
2I2U_N (145475) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.2Å No No
2QAL_N (150227) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.21Å No No
2QAN_N (150281) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.21Å No No
2QB9_N (150341) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.54Å Yes No
2QBB_N (150394) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.54Å Yes No
2QBD_N (150447) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.3Å Yes No
2QBF_N (150501) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.3Å Yes No
2QBH_N (150555) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 4Å Yes No
2QBJ_N (150609) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 4Å Yes No
2QOU_N (150998) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.93Å Yes No
2QOW_N (151051) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.93Å No No
2QOY_N (151104) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.5Å Yes No
2QP0_N (151157) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.5Å No No
2VHO_N (153136) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.74Å No No
2VHP_N (153158) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.74Å No No
2WWL_N (3260088) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 5.8Å Yes No
2Z4K_N (154065) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 4.45Å Yes No
2Z4M_N (154119) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 4.45Å Yes No
3DF1_N (157616) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.5Å Yes No
3DF3_N (157670) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.5Å Yes No
3FIH_N (3410175) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 6.7Å Yes No
3I1M_N (4191317) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3I1M 3.19Å Yes No
3I1O_N (4118401) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3I1O 3.19Å Yes No
3I1Q_N (4202801) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3I1Q 3.8Å Yes No
3I1S_N (4093896) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3I1S 3.8Å Yes No
3I1Z_N (4002593) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3I1Z 3.7Å Yes No
3I21_N (4168539) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3I21 3.7Å Yes No
3IZV_R (3620485) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 13.2Å Yes No
3IZW_R (3620513) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 8.25Å Yes No
3KC4_N (3500319) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 9.6Å Yes No
3OAQ_N (3650097) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.25Å Yes No
3OAR_N (3650119) 30S ribosomal protein S14 Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Ribosomal protein S14 3.25Å Yes No
3OFA_N (4107310) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3OFA 3.19Å Yes No
3OFB_N (4119981) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3OFB 3.19Å Yes No
3OFO_N (4043267) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3OFO 3.1Å Yes No
3OFP_N (4241445) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3OFP 3.1Å Yes No
3OFX_N (4118819) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3OFX 3.289Å No No
3OFY_N (4006349) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3OFY 3.289Å Yes No
3OR9_N (4224952) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3OR9 3Å No No
3ORA_N (4201799) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3ORA 3Å Yes No
3R8N_N (4128228) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3R8N 3Å Yes No
3R8O_N (4109743) 30S ribosomal protein S14 UNMATCHED, UNMATCHED, UNMATCHED 3R8O 3Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score