Molecular Target Synopsis
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fabI (P0AEK4) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed52
Chains with at least one site assessed as druggable using the strict criteria49
Chains with at least one site assessed as druggable using the relaxed criteria52


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1DFH_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 72.6 33 Yes Yes
2 empty 2.02 68.7 20.6 No No
3 empty 2.46 67.3 17 No No
4 empty 1.73 67.8 17.1 No No
5 empty 1.9 64.8 13.8 No No
6 empty 2.38 62.7 22.3 No No
7 empty 2.31 59.6 19.3 No No
8 empty 2.3 61.9 18.6 No No
9 empty 2.21 62.7 18.3 No No
10 empty 1.78 53.3 14.2 No No
1I2Z_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 74 41.3 Yes Yes
2 empty 2.59 66 21.6 No No
3 empty 1.77 67.5 17 No No
4 empty 2.05 60.6 20 No No
5 empty 1.68 64 17 No No
6 empty 2.27 65.4 13.7 No No
7 empty 2.15 56.7 19.7 No No
8 empty 1.78 54.3 14 No No
9 empty 1.45 72.9 10.1 No No
10 empty 2.52 75 7.9 No No
5CG2_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 65.8 42.7 Yes No
2 empty 1.88 67.2 17 No No
3 empty 2.48 69.4 16.1 No No
4 empty 1.88 64.5 19.7 No No
5 empty 2.25 63.8 16.2 No No
6 empty 2.09 60.3 21.9 No No
7 empty 1.81 55.2 13.1 No No
8 empty 2.18 60.1 19 No No
9 empty 2.13 69.8 11.3 No No
10 empty 2.22 73.7 8.3 No No
1QG6_C Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.41 74 34.5 Yes Yes
2 empty 1.92 66.5 19.9 No No
3 empty 2.47 64.1 28.6 No No
4 empty 1.81 68.8 17.3 No No
5 empty 1.84 62.9 18.6 No No
6 empty 2.3 65.2 16.1 No No
7 empty 1.88 56.3 13.3 No No
8 empty 1.9 70.1 8.5 No No
9 empty 2.33 66.1 9.2 No No
10 empty 2.46 78.8 8.3 No No
4JX8_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 69.2 43.4 Yes Yes
2 empty 1.89 66.2 16.5 No No
3 empty 2.28 63.5 14.4 No No
4 empty 1.84 53.3 11.4 No No
5 empty 1.92 65.4 13.5 No No
6 empty 2.38 56.9 12.7 No No
7 empty 2.69 66.5 10 No No
8 empty 1.87 66.1 10.2 No No
9 empty 2.75 58 8.1 No No
10 empty 1.95 74.4 8.8 No No
1DFI_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 67.7 44.7 Yes Yes
2 empty 1.89 66 17.6 No No
3 empty 1.83 61.4 14.1 No No
4 empty 2.14 70.9 15.5 No No
5 empty 2.32 59.7 20.1 No No
6 empty 2.03 57.2 12.4 No No
7 empty 2.28 59.4 14.9 No No
8 empty 2.51 58.3 13 No No
9 empty 2.53 68 9.9 No No
10 empty 2.24 68.5 7.9 No No
5CFZ_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.45 69.7 42.8 Yes Yes
2 empty 2.39 63.3 16.1 No No
3 empty 1.9 69.8 17.3 No No
4 empty 1.85 67.4 14.5 No No
5 empty 1.77 65.8 15.6 No No
6 empty 1.92 68.6 12.5 No No
7 empty 1.94 54.9 13.5 No No
8 empty 2.48 67.8 8.9 No No
9 empty 2.29 64.8 13.5 No No
10 empty 2.19 60.2 11.6 No No
1C14_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.41 75.8 35.7 Yes Yes
2 empty 1.98 70.8 20 No No
3 empty 1.73 68.8 17.1 No No
4 empty 1.78 62.9 12.8 No No
5 empty 2.27 65.3 15.1 No No
6 empty 1.76 56.7 11.3 No No
7 empty 1.82 63.5 14 No No
8 empty 2.26 67.5 7.9 No No
9 empty 1.72 66.8 9.4 No No
10 empty 2.66 73.4 10.4 No No
1I30_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 70.1 46.2 Yes Yes
2 empty 1.82 67.3 16.3 No No
3 empty 1.82 65.4 18.5 No No
4 empty 2.21 58.8 20.3 No No
5 empty 1.84 56.9 11.8 No No
6 empty 2.16 61.2 18.2 No No
7 empty 2.61 72.8 8.7 No No
8 empty 2.54 64.9 12.9 No No
9 empty 1.87 66.9 8.4 No No
10 empty 2.12 62.1 7.5 No No
3PJE_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 76.1 32.7 Yes Yes
2 empty 2.43 66.2 22.1 No No
3 empty 2.08 66.3 19.9 No No
4 empty 1.81 64.2 15.6 No No
5 empty 1.75 66.2 17.6 No No
6 empty 2.23 62 19.6 No No
7 empty 1.99 55 12.1 No No
8 empty 2.14 60.4 11.7 No No
9 empty 2.63 71.5 9.3 No No
10 empty 2.36 71 7.3 No No
1QG6_D Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 75.4 32.9 Yes Yes
2 empty 1.91 67.7 18.1 No No
3 empty 1.73 67.5 16.6 No No
4 empty 2.49 66.5 17.2 No No
5 empty 1.84 65.5 16 No No
6 empty 1.9 69.9 8.7 No No
7 empty 2.03 57.1 13.9 No No
8 empty 2.02 60.4 14.5 No No
9 empty 2.09 67.4 12 No No
10 empty 2.48 73.5 8.5 No No
1LXC_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 72.8 44.6 Yes Yes
2 empty 1.88 67.1 17.8 No No
3 empty 2.49 67.8 19.4 No No
4 empty 1.86 63.8 13.5 No No
5 empty 1.89 64.2 15.3 No No
6 empty 2.31 62 15.9 No No
7 empty 2.12 62.8 20.5 No No
8 empty 1.77 53.2 11.3 No No
9 empty 2.09 63.2 13 No No
10 empty 1.84 72 8 No No
5CFZ_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 69.9 42.9 Yes Yes
2 empty 1.85 69.3 12.2 No No
3 empty 2.47 67.5 17.9 No No
4 empty 1.87 64.1 17.5 No No
5 empty 2.19 59.7 19.3 No No
6 empty 2.28 62.3 16.9 No No
7 empty 1.89 55.4 14.6 No No
8 empty 2.16 73.1 10.3 No No
9 empty 2.28 53.7 12.1 No No
10 empty 2.48 63.4 7.5 No No
1DFG_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 75 35.1 Yes Yes
2 empty 2.08 70.1 19.7 No No
3 empty 1.73 66.7 16.8 No No
4 empty 2.36 67.6 11.9 No No
5 empty 2.35 65.5 20.4 No No
6 empty 2.38 59.4 18.4 No No
7 empty 1.86 63.6 14.4 No No
8 empty 2.05 72.6 12.7 No No
9 empty 1.83 50.5 14.2 No No
10 empty 2.2 67.8 9.1 No No
1LXC_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 70 44.5 Yes Yes
2 empty 1.87 67.1 13.4 No No
3 empty 1.93 65.1 16.4 No No
4 empty 2.15 64.1 15.4 No No
5 empty 2.41 59.8 23.7 No No
6 empty 2.56 69.7 14.3 No No
7 empty 2.11 58.3 19.5 No No
8 empty 1.9 53.9 14.3 No No
9 empty 2.45 78.7 8.2 No No
10 empty 1.8 62.3 8.5 No No
1QSG_E Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 76 27.7 Yes Yes
2 empty 2.05 64.8 21.6 No No
3 empty 1.69 63.6 17.1 No No
4 empty 1.67 62.2 15.6 No No
5 empty 1.77 64.9 11 No No
6 empty 2.3 60.6 13.2 No No
7 empty 1.76 51.2 12.8 No No
8 empty 1.89 63.2 12.8 No No
9 empty 2.42 61.8 12 No No
10 empty 2.33 64.8 8.9 No No
5CG1_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 72.2 42.2 Yes Yes
2 empty 2.5 66.9 24.1 No No
3 empty 1.85 70.3 14.9 No No
4 empty 1.87 63.8 14.7 No No
5 empty 2.17 64.2 17.5 No No
6 empty 2.12 60.3 17.6 No No
7 empty 1.78 54.7 12.4 No No
8 empty 1.74 69.6 12 No No
9 empty 1.8 72 7.7 No No
10 empty 2.53 76.4 8.9 No No
1QSG_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 77.3 24.2 Yes Yes
2 empty 1.97 66.3 21.4 No No
3 empty 1.67 66.4 17.3 No No
4 bound 2.23 54.1 17.7 No No
5 empty 1.81 63 17 No No
6 empty 2.13 55.1 14 No No
7 empty 2.05 57 13 No No
8 empty 1.67 49.6 13.9 No No
9 empty 2.19 63.2 10.4 No No
10 empty 2.52 63.8 9.1 No No
1D8A_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 79.5 31.5 Yes Yes
2 empty 2.08 67.7 21.6 No No
3 empty 2.12 68.4 17 No No
4 empty 1.71 67.4 17.8 No No
5 empty 2.45 67.4 19.5 No No
6 empty 1.86 65.2 17.7 No No
7 empty 2.31 59.6 17.5 No No
8 empty 2.4 60.3 12.3 No No
9 empty 2.18 60.7 19.5 No No
10 empty 1.79 51.9 11.5 No No
1QG6_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 73.4 40.2 Yes Yes
2 empty 1.94 68.5 20.2 No No
3 empty 1.71 66.2 17.8 No No
4 empty 2.49 66.4 15.5 No No
5 empty 2.27 61.7 17.4 No No
6 empty 1.86 66.9 10.5 No No
7 empty 2.02 55.4 11.4 No No
8 empty 2.17 61.7 11.2 No No
9 empty 2.36 65.7 11.9 No No
10 empty 2.44 78.7 8.7 No No
1D8A_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 76.6 33.9 Yes Yes
2 empty 2.1 71.4 24.8 No No
3 empty 2.14 63.8 24.6 No No
4 empty 1.75 66.8 17.3 No No
5 empty 2.42 68.3 14.9 No No
6 empty 1.9 67.6 12.8 No No
7 empty 2.42 62 21.3 No No
8 empty 1.96 61.3 13.5 No No
9 empty 1.77 54.6 14.6 No No
10 empty 2.35 72.3 7.9 No No
1QSG_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 81.4 23.8 Yes Yes
2 empty 2.03 62.7 18.8 No No
3 bound 2.31 56.6 17.6 No No
4 empty 1.7 65.2 17.6 No No
5 empty 1.82 60.4 15.1 No No
6 empty 2.04 60.9 13.1 No No
7 empty 2.19 52.7 13.1 No No
8 empty 1.82 49.1 13.3 No No
9 empty 1.4 68.4 12.9 No No
10 empty 2.49 65.6 10.6 No No
1DFG_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 71.5 35.3 Yes Yes
2 empty 1.9 74 19.3 No No
3 empty 1.72 66 17.6 No No
4 empty 2.52 69.3 18.1 No No
5 empty 2.32 58.7 19.5 No No
6 empty 2.21 64.8 22.9 No No
7 empty 2.22 66.1 13.4 No No
8 empty 1.74 52.2 13.1 No No
9 empty 1.8 68.4 11.4 No No
10 empty 1.73 64.3 10.4 No No
1QSG_F Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 79.4 24.4 Yes Yes
2 empty 1.96 66.1 18.2 No No
3 bound 2.19 54.9 17.7 No No
4 empty 1.72 65.1 17.8 No No
5 empty 1.87 60.2 16.6 No No
6 empty 1.78 47.9 15 No No
7 empty 1.94 57.2 12.5 No No
8 empty 2.19 57 14.7 No No
9 empty 1.41 68.8 10 No No
10 empty 2.58 63.9 8.6 No No
1LX6_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 69.1 43 Yes Yes
2 empty 1.9 66.3 17.4 No No
3 empty 1.77 64.7 13.9 No No
4 empty 2.56 69.9 11.8 No No
5 empty 1.77 58.7 14.9 No No
6 empty 2.23 62.8 20.4 No No
7 empty 2.26 64.8 13.5 No No
8 empty 2.11 60.3 20.5 No No
9 empty 1.88 52.4 12.8 No No
10 empty 1.93 46.8 11.4 No No
3PJD_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 75.6 32.1 Yes Yes
2 empty 2.23 64.1 22.6 No No
3 empty 1.95 67.9 22.1 No No
4 empty 1.71 65.3 17.6 No No
5 empty 1.85 63.1 16.1 No No
6 empty 2.31 63.8 18.8 No No
7 empty 2.33 62.3 13.8 No No
8 empty 2.16 61.8 20.1 No No
9 empty 2.02 52 12.6 No No
10 empty 2.55 71.8 8.2 No No
1QSG_G Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 79.9 22.5 Yes Yes
2 empty 1.82 67.3 22.4 No No
3 empty 1.7 66.6 18 No No
4 empty 1.79 63.2 14.5 No No
5 bound 2.38 59.4 13.8 No No
6 empty 1.86 65.8 14.8 No No
7 empty 1.83 50.3 14.1 No No
8 empty 2.46 64.5 14.1 No No
9 empty 2.1 55.6 12.8 No No
10 empty 2.09 60.6 12.9 No No
2FHS_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.46 65.1 41.5 Yes No
2 empty 1.88 68.4 17.2 No No
3 empty 2.28 65.6 19.6 No No
4 empty 2.1 56.1 22.8 No No
5 empty 1.83 48.3 12.3 No No
6 empty 1.81 71.2 8.4 No No
7 empty 2.08 66.4 9.8 No No
8 empty 2.23 65.8 10.7 No No
9 empty 2.05 62.7 10.7 No No
10 empty 2.68 65.1 10.3 No No
1QSG_C Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 76.9 26.6 Yes Yes
2 empty 2.05 69.5 20.9 No No
3 empty 2.16 59.6 20.7 No No
4 empty 1.68 66.7 18.6 No No
5 empty 1.7 59.3 15.1 No No
6 empty 2.36 58.2 14.3 No No
7 empty 2.54 62.7 9.9 No No
8 empty 1.8 50.9 14.3 No No
9 empty 2 57.2 14.3 No No
10 empty 2.51 64.3 11 No No
1I30_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 71.3 43.3 Yes Yes
2 empty 2.56 62.8 26.6 No No
3 empty 2.29 67.7 16.7 No No
4 empty 1.91 69 17.1 No No
5 empty 1.84 65.6 16.1 No No
6 empty 1.77 52.3 14.4 No No
7 empty 2.13 58.2 18.3 No No
8 empty 1.91 64.8 11.6 No No
9 empty 2.46 75.3 8 No No
10 empty 1.89 69.4 8.1 No No
1DFI_D Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 66.9 51.9 Yes Yes
2 empty 1.88 64.6 17.4 No No
3 empty 2.42 70.1 13.9 No No
4 empty 2.28 60.7 22.2 No No
5 empty 2.27 76.5 8.1 No No
6 empty 1.99 52.6 12.3 No No
7 empty 2.43 67.5 11.5 No No
8 empty 2.67 73.9 12.2 No No
9 empty 2.24 68.6 8.9 No No
10 empty 2.33 71.1 8.2 No No
1QSG_D Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.5 83.6 23.1 Yes Yes
2 empty 2.03 68 21.7 No No
3 empty 1.69 63.3 18.2 No No
4 empty 2.17 62.2 19.3 No No
5 bound 2.19 60.2 17.8 No No
6 empty 1.78 63.9 13.8 No No
7 empty 2.33 51.5 14.8 No No
8 empty 1.81 50.5 13.6 No No
9 empty 2.02 61.6 11.2 No No
10 empty 1.81 58.7 13.3 No No
1MFP_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.52 78.6 30.9 Yes Yes
2 empty 2 64.8 21.3 No No
3 empty 1.75 65.7 17.5 No No
4 empty 1.83 64.3 15.7 No No
5 empty 2.14 69.4 13.3 No No
6 empty 2.48 68.6 14.1 No No
7 empty 2.32 61.3 19.8 No No
8 empty 2.42 65.5 13.6 No No
9 empty 2.16 60.5 20.4 No No
10 empty 1.89 53 12.6 No No
4JQC_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 76.4 43.4 Yes Yes
2 empty 1.82 65.3 15.1 No No
3 empty 1.91 61.1 19.8 No No
4 empty 2.5 71 15.8 No No
5 empty 1.82 67.8 17 No No
6 empty 2.18 59.4 16.6 No No
7 empty 2.22 61.6 13.3 No No
8 empty 1.78 51.6 13.7 No No
9 empty 1.95 70.6 10.1 No No
10 empty 2.25 66.9 9.5 No No
1I2Z_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.5 73.3 46.2 Yes Yes
2 empty 1.77 68 18.2 No No
3 empty 1.82 65.2 14.3 No No
4 empty 2.53 67.5 18.6 No No
5 empty 2.01 65.4 13.4 No No
6 empty 2.24 65.6 14.6 No No
7 empty 1.74 53.1 12.8 No No
8 empty 2.02 63.7 13 No No
9 empty 2.16 58.5 11.3 No No
10 empty 2.39 59.1 11.9 No No
3PJF_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 71 40.7 Yes Yes
2 empty 1.9 67.1 17.5 No No
3 empty 1.77 66.5 13.6 No No
4 empty 2.17 64.2 17.4 No No
5 empty 1.77 51.4 11.9 No No
6 empty 2.14 60 18.2 No No
7 empty 2.54 67 12.5 No No
8 empty 2.32 69.3 11.8 No No
9 empty 1.95 54.9 12.4 No No
10 empty 2.15 70.2 7.5 No No
4JX8_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 80.6 37.6 Yes Yes
2 empty 2.28 66.6 16 No No
3 empty 1.8 69.1 16 No No
4 empty 1.82 62.9 13.5 No No
5 empty 1.95 59.4 18 No No
6 empty 1.87 49.2 11.9 No No
7 empty 1.99 62 13.7 No No
8 empty 2.2 66.3 11.5 No No
9 empty 2.63 66.9 8.4 No No
10 empty 2.86 60.6 8.7 No No
1DFI_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 69.9 41.4 Yes Yes
2 empty 2.21 67.7 18.4 No No
3 empty 1.83 66.5 13.7 No No
4 empty 1.89 65.2 17.1 No No
5 empty 2.3 64.2 18.4 No No
6 empty 2.08 62.6 19.7 No No
7 empty 2.05 56.5 11.4 No No
8 empty 2.52 66.8 12.8 No No
9 empty 1.95 64.9 12.1 No No
10 empty 2.63 70.4 9.5 No No
3PJE_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.35 75.9 44.7 Yes Yes
2 empty 1.7 67 17.1 No No
3 empty 1.83 64.5 15.4 No No
4 empty 2.17 63.5 18.5 No No
5 empty 1.91 68.8 8.2 No No
6 empty 1.77 51.3 13.7 No No
7 empty 2.4 67.3 12.7 No No
8 empty 2.05 63.3 13 No No
9 empty 2.38 65.4 14.1 No No
10 empty 2.11 58.1 16.4 No No
1MFP_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 78 37.2 Yes Yes
2 empty 1.97 65.9 20.9 No No
3 empty 2.66 61.5 19.8 No No
4 empty 1.71 62.6 14.3 No No
5 empty 1.74 69.7 17.1 No No
6 empty 1.86 53.2 11.3 No No
7 empty 1.91 60.9 14 No No
8 empty 2.44 66.2 9.1 No No
9 empty 1.8 73 8.5 No No
10 empty 2.31 77.5 10.7 No No
1DFI_C Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 68.4 41.9 Yes Yes
2 empty 2.62 62 31.3 No No
3 empty 1.89 69.9 13.1 No No
4 empty 1.89 61 17.8 No No
5 empty 2.17 65.9 12 No No
6 empty 2.01 59.5 12.9 No No
7 empty 2.05 67.4 11.6 No No
8 empty 1.8 55.6 11.8 No No
9 empty 2.49 78.5 7.9 No No
10 empty 2.12 71.7 8.7 No No
1QSG_H Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.46 71.8 32.6 Yes Yes
2 empty 1.93 66.1 19.4 No No
3 empty 1.76 62.3 18.2 No No
4 empty 2 65.8 13.9 No No
5 empty 2.14 60.3 13.9 No No
6 empty 2 56.7 13.7 No No
7 empty 1.78 52.1 13.7 No No
8 empty 1.64 69.6 10.6 No No
9 empty 1.68 56.5 12.7 No No
10 empty 2.43 62.1 11.5 No No
2FHS_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.55 65.9 42.6 Yes No
2 empty 1.89 68.1 11.9 No No
3 empty 1.84 67 15.9 No No
4 empty 2.46 55.8 20.2 No No
5 empty 2.21 60.4 15.7 No No
6 empty 1.82 53.8 11.1 No No
7 empty 2.5 66.4 10.6 No No
8 empty 1.82 73.5 7.8 No No
9 empty 1.88 59.8 9.9 No No
10 empty 2.56 77.4 8.4 No No
1QG6_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 75.4 34.1 Yes Yes
2 empty 1.93 69 20.1 No No
3 empty 1.73 68 16.2 No No
4 empty 1.82 65.6 13.8 No No
5 empty 1.84 70.1 10.9 No No
6 empty 2.02 53.2 13.7 No No
7 empty 2.08 65.6 13.4 No No
8 empty 2.08 65.5 13 No No
9 empty 2.58 69.3 10.3 No No
10 empty 2.28 67 9.3 No No
4JQC_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 71.8 51.5 Yes Yes
2 empty 2.4 68.2 21.8 No No
3 empty 2.4 69.2 16.9 No No
4 empty 1.82 68 15.5 No No
5 empty 2.34 63.7 21.9 No No
6 empty 2.27 60.1 19.2 No No
7 empty 1.79 52.4 13.6 No No
8 empty 2.2 70.3 11.9 No No
9 empty 2.64 59.8 8.6 No No
10 empty 1.88 60 11.2 No No
3PJD_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.38 78.3 32.7 Yes Yes
2 empty 1.95 67.5 20.5 No No
3 empty 2.67 63.9 22.9 No No
4 empty 1.71 66.4 17.2 No No
5 empty 1.9 64.3 15.1 No No
6 empty 2.49 67.1 21.1 No No
7 empty 2.31 70 16.2 No No
8 empty 2.25 59.3 22 No No
9 empty 2.54 67 14.8 No No
10 empty 1.81 54.2 14.3 No No
1LX6_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 67 43.4 Yes Yes
2 empty 2.62 62.5 24.3 No No
3 empty 1.9 68.3 17.5 No No
4 empty 1.83 66 13.4 No No
5 empty 2.09 61 13 No No
6 empty 1.79 54.7 12.2 No No
7 empty 1.9 52.8 9.8 No No
8 empty 2.4 72.7 8.2 No No
9 empty 2.62 61.5 9.4 No No
10 empty 2.15 60.4 10.4 No No
1DFH_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 69.6 36.9 Yes Yes
2 empty 1.99 70 20.9 No No
3 empty 1.71 68.3 16.8 No No
4 empty 1.8 63.6 16.6 No No
5 empty 1.88 63.4 14.2 No No
6 empty 2.38 64.6 16.1 No No
7 empty 2.1 62.2 13.7 No No
8 empty 1.78 51.2 11.3 No No
9 empty 2.44 69.5 10.1 No No
10 empty 2.27 70.7 7.6 No No
5CG1_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 67.4 42.9 Yes Yes
2 empty 1.84 69.1 14.4 No No
3 empty 1.78 65.4 12.8 No No
4 empty 2.22 62.6 17.5 No No
5 empty 1.78 53.6 14.6 No No
6 empty 2.09 61.2 10.2 No No
7 empty 2.55 70.3 13.3 No No
8 empty 1.92 71.7 8.6 No No
9 empty 2.33 66.5 9.4 No No
10 empty 2.77 55.8 11.5 No No
1C14_A Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.45 75 34.5 Yes Yes
2 empty 2.07 69.6 21.8 No No
3 empty 1.75 69.4 14.8 No No
4 empty 2.16 60.3 17.7 No No
5 empty 1.84 66.3 13.4 No No
6 empty 1.76 51.8 12.5 No No
7 empty 2.13 54.2 21 No No
8 empty 2.08 61.4 13.4 No No
9 empty 1.9 67.1 16.7 No No
10 empty 2.25 63.6 8.1 No No
3PJF_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.38 73.3 43.8 Yes Yes
2 empty 2.27 66.5 13.9 No No
3 empty 1.89 70.4 14.7 No No
4 empty 1.64 65.9 15.3 No No
5 empty 2.18 56.5 19.9 No No
6 empty 2.15 70.8 10.4 No No
7 empty 1.8 50.5 12.7 No No
8 empty 2.29 55.9 18.6 No No
9 empty 2.51 69.7 9 No No
10 empty 2.52 73.1 7.8 No No
5CG2_B Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.65 69.6 31 Yes Yes
2 empty 1.82 59.7 22.7 No No
3 empty 2.06 62.4 21.3 No No
4 empty 1.88 68.8 16.7 No No
5 empty 1.77 67.3 13.7 No No
6 empty 2.16 59.7 20.1 No No
7 empty 2.04 64.9 12.6 No No
8 empty 1.79 54 11.9 No No
9 empty 1.71 57.5 12.7 No No
10 empty 2.54 66.4 12.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed53
Domains assessed as druggable using the strict criteria47
Domains assessed as druggable using the relaxed criteria53

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1C14_B (4059334) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2Å Yes No
1C14_A (29927) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2Å Yes Yes
1C14_B (29928) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2Å Yes Yes
1C14_A (4059334) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2Å Yes No
1D8A_A (29931) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.18Å Yes Yes
1D8A_B (4050473) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.18Å Yes Yes
1D8A_A (4050473) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.18Å Yes Yes
1D8A_B (29932) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.18Å Yes Yes
1DFG_B (29934) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.5Å Yes Yes
1DFG_A (29933) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.5Å Yes Yes
1DFG_B (4074996) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.5Å Yes Yes
1DFG_A (4074996) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.5Å Yes Yes
1DFH_B (4205513) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.2Å Yes Yes
1DFH_A (29929) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.2Å Yes Yes
1DFH_A (4205513) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.2Å Yes Yes
1DFH_B (29930) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.2Å Yes Yes
1DFI_D (29926) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.08Å Yes Yes
1DFI_C (29925) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.08Å Yes Yes
1DFI_A (29923) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.08Å Yes Yes
1DFI_B (29924) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.08Å Yes Yes
1DFI_A (4205243) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.08Å Yes Yes
1DFI_C (4205243) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.08Å Yes Yes
1DFI_D (4205243) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.08Å Yes Yes
1DFI_B (4205243) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.08Å Yes Yes
1I2Z_B (4236835) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.8Å Yes Yes
1I2Z_A (4236835) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.8Å Yes Yes
1I2Z_B (65990) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.8Å Yes Yes
1I2Z_A (65989) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.8Å Yes Yes
1I30_B (4097759) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.3Å Yes Yes
1I30_A (4097759) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.3Å Yes Yes
1I30_A (65991) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.3Å Yes Yes
1I30_B (65992) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.3Å Yes Yes
1LX6_A (4113499) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.4Å Yes No
1LX6_B (4113499) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.4Å Yes No
1LX6_B (78288) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.4Å Yes Yes
1LX6_A (78287) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.4Å Yes Yes
1LXC_B (4245270) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.4Å Yes Yes
1LXC_B (78290) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.4Å Yes Yes
1LXC_A (78289) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.4Å Yes Yes
1LXC_A (4245270) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.4Å Yes Yes
1MFP_B (4189884) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.33Å Yes No
1MFP_B (84939) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.33Å Yes Yes
1MFP_A (84938) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.33Å Yes Yes
1MFP_A (4189884) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.33Å Yes No
1QG6_A (29919) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.9Å Yes Yes
1QG6_B (29920) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.9Å Yes Yes
1QG6_C (29921) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.9Å Yes Yes
1QG6_D (29922) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.9Å Yes Yes
1QG6_B (4222019) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.9Å Yes Yes
1QG6_D (4222019) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.9Å Yes Yes
1QG6_C (4222019) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.9Å Yes Yes
1QG6_A (4222019) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.9Å Yes Yes
1QSG_D (29938) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.75Å Yes Yes
1QSG_A (29935) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.75Å Yes Yes
1QSG_F (4073261) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.75Å Yes Yes
1QSG_G (4073261) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.75Å Yes Yes
1QSG_H (4073261) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.75Å Yes Yes
1QSG_E (4073261) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.75Å Yes Yes
1QSG_A (4218059) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.75Å Yes Yes
1QSG_C (4218059) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.75Å Yes Yes
1QSG_D (4218059) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.75Å Yes Yes
1QSG_B (4218059) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.75Å Yes Yes
1QSG_H (29942) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.75Å Yes Yes
1QSG_B (29936) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.75Å Yes Yes
1QSG_C (29937) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.75Å Yes Yes
1QSG_E (29939) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.75Å Yes Yes
1QSG_F (29940) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.75Å Yes Yes
1QSG_G (29941) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 1.75Å Yes Yes
2FHS_B (4133158) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.7Å Yes No
2FHS_A (4133158) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.7Å Yes No
2FHS_B (133502) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.7Å Yes No
2FHS_A (133501) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases 2.7Å Yes No
3PJD_A (4262858) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.5Å Yes Yes
3PJD_B (4262858) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.5Å Yes Yes
3PJE_B (4213129) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.5Å Yes Yes
3PJE_A (4213129) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 2.5Å Yes Yes
3PJF_B (4236694) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.9Å Yes Yes
3PJF_A (4236694) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Tyrosine-dependent oxidoreductases (Homo Multimer) 1.9Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score