Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

fabI (P0AEK4) - Overview - Molecular Target Synopsis

Protein


fabI, Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Enzyme Classification 1.3.1.9
UniProt P0AEK4

Also Known as FABI_ECOLI, fabI, envM

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis. Homotetramer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Drugs


fabI is targeted by Approved Drugs Hexachlorophene, Triclosan. (see details)
Hexachlorophene
Triclosan

Sub-cellular localization


GO terms: fabI is active in the following subcellular-locations: cytosol, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project fabI has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For fabI there are:
21 structures (52 chains) solved
19 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


fabI has been screened with 107 compounds (184 bioactivities), 11 compounds have bioactivities that show binding affinity of <= 500nM (15 bioactivities). (see details)