Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

bla (P0AD64) - Overview - Molecular Target Synopsis

Protein


bla, Beta-lactamase SHV-1
Enzyme Classification 3.5.2.6
UniProt P0AD64

Also Known as BLA1_KLEPN, bla, shv1


4ZAM
CRYSTAL STRUCTURE OF SHV-1 BETA-LACTAMASE BOUND TO AVIBACTAM
RCSB/PDB
Inspect Structure
See all 3D Structures for bla

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
286P0AD64-1, P0AD63-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project bla has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For bla there are:
42 structures (42 chains) solved
37 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

bla is solved in complex with the approved drug(s):

0RN/SULBACTAM (4FH2_A),
TAU/TAURINE (4FCF_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


bla has been screened with 23 compounds (125 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (7 bioactivities). (see details)