Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rutR (P0ACU2) - Overview - Molecular Target Synopsis

Protein


rutR, HTH-type transcriptional regulator RutR
UniProt P0ACU2

Also Known as RUTR_ECOLI, rutR, ycdC

Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX). Homodimer.

4XK4
E. COLI TRANSCRIPTIONAL REGULATOR RUTR WITH DIHYDROURACIL
RCSB/PDB
Inspect Structure
See all 3D Structures for rutR

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rutR is active in the following subcellular-locations: protein-DNA complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rutR has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rutR there are:
3 structures (10 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis