iscU, Iron-sulfur cluster assembly scaffold protein IscU
Also Known as
ISCU_ECOLI, iscU, nifU, yfhN
A scaffold on which IscS assembles Fe-S clusters. Exists as 2 interconverting forms, a structured (S) and disordered (D) form. The D-state is the preferred substrate for IscS. Converts to the S-state when an Fe-S cluster is assembled, which helps it dissociate from IscS to transfer the Fe-S to an acceptor. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. Homodimer. Forms a heterotetramer with IscS; each subunit of the IscS dimer contacts an IscU monomer.