Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

iscU (P0ACD4) - Overview - Molecular Target Synopsis

Protein


iscU, Iron-sulfur cluster assembly scaffold protein IscU
UniProt P0ACD4

Also Known as ISCU_ECOLI, iscU, nifU, yfhN

A scaffold on which IscS assembles Fe-S clusters. Exists as 2 interconverting forms, a structured (S) and disordered (D) form. The D-state is the preferred substrate for IscS. Converts to the S-state when an Fe-S cluster is assembled, which helps it dissociate from IscS to transfer the Fe-S to an acceptor. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. Homodimer. Forms a heterotetramer with IscS; each subunit of the IscS dimer contacts an IscU monomer.

2L4X
SOLUTION STRUCTURE OF APO-ISCU(WT)
RCSB/PDB
Inspect Structure
See all 3D Structures for iscU

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
128P0ACD4-1, P0ACD6-1, P0ACD5-1, P0ACD7-1

Sub-cellular localization


GO terms: iscU is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project iscU has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For iscU there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis