Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

folA (P0ABQ4) - Overview - Molecular Target Synopsis

Protein


folA, Dihydrofolate reductase
Enzyme Classification 1.5.1.3
UniProt P0ABQ4

Also Known as DYR_ECOLI, folA, tmrA

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

6MT8
E. COLI DHFR COMPLEX MODELED WITH TWO LIGAND STATES
RCSB/PDB
Inspect Structure
See all 3D Structures for folA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Drugs


folA is targeted by Approved Drug Trimethoprim. (see details)
Trimethoprim

Sub-cellular localization


GO terms: folA is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project folA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For folA there are:
91 structures (125 chains) solved
87 are solved in complex with at least one small molecule ligand
56 are solved with an approved drug

folA is solved in complex with the approved drug(s):

MTX/METHOTREXATE (1DDR_A, 1DDR_B, 1DDS_A, 1DDS_B, 1DHI_A, 1DHI_B, 1DHJ_A, 1DHJ_B, 1DRA_A, 1DRA_B, 1DRB_A, 1DRB_B, 1DRE_A, 1RA3_A, 1RB3_A, 1RB3_B, 1RG7_A, 1RH3_A, 1RX3_A, 1TDR_A, 1TDR_B, 2DRC_A, 2DRC_B, 3DAU_A, 3DRC_A, 3DRC_B, 4DFR_A, 4DFR_B, 4GH8_A, 4GH8_B),
FOL/FOLIC ACID (1DYI_A, 1DYI_B, 1RA2_A, 1RA8_A, 1RB2_A, 1RB2_B, 1RD7_A, 1RD7_B, 1RE7_A, 1RE7_B, 1RX2_A, 1RX7_A, 1RX8_A, 2D0K_A, 2D0K_B, 3QL3_A, 4EJ1_A, 4EJ1_B, 4FHB_A, 4I13_A, 4I1N_A, 4KJJ_A, 4KJK_A, 4KJL_A, 4NX6_A, 4NX7_A, 4X5F_A, 4X5F_B, 4X5G_A, 4X5G_B, 4X5H_A, 4X5I_A, 4X5J_A, 5E8Q_A, 5E8Q_B, 5EAJ_A, 5EAJ_B, 5UJX_A, 5UJX_B, 5Z6F_A, 5Z6J_A, 5Z6K_A, 5Z6L_A, 5Z6M_A, 7DFR_A),
8CV/PHENFORMIN (5UIH_A),
FFO/LEVOLEUCOVORIN (1JOL_A, 1JOL_B, 1JOM_A),
BFR/BUFORMIN (5UII_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


folA has been screened with 157 compounds (225 bioactivities), 56 compounds have bioactivities that show binding affinity of <= 500nM (82 bioactivities). (see details)