Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

cybC (P0ABE7) - Overview - Molecular Target Synopsis

Protein


cybC, Soluble cytochrome b562
UniProt P0ABE7

Also Known as C562_ECOLX, cybC

Electron-transport protein of unknown function. Monomer.

6GT3
CRYSTAL STRUCTURE OF THE A2A-STAR2-BRIL562 IN COMPLEX WITH AZD4635 AT 2.0A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for cybC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
128P0ABE7-1

Sub-cellular localization


UniProt: cybC is active in the following subcellular-locations: periplasm.
GO terms: cybC is active in the following subcellular-locations: periplasmic space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project cybC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For cybC there are:
164 structures (324 chains) solved
148 are solved in complex with at least one small molecule ligand
55 are solved with an approved drug

cybC is solved in complex with the approved drug(s):

8NU/RISPERIDONE (6A93_A, 6A93_B),
CLR/CHOLESTEROL (4EIY_A, 4IB4_A, 4NC3_A, 4NTJ_A, 4OR2_A, 4OR2_B, 4PXZ_A, 5IU4_A, 5IU7_A, 5IU8_A, 5IUA_A, 5IUB_A, 5JTB_A, 5K2A_A, 5K2B_A, 5K2C_A, 5K2D_A, 5L7D_A, 5MZJ_A, 5MZP_A, 5N2R_A, 5NLX_A, 5NM2_A, 5NM4_A, 5OLG_A, 5OLH_A, 5OLO_A, 5OLV_A, 5OLZ_A, 5OM1_A, 5OM4_A, 5TVN_A, 5UVI_A, 5VRA_A, 6A93_A, 6A93_B, 6A94_A, 6A94_B, 6AQF_A, 6B73_A, 6B73_B, 6D35_A, 6DRX_A, 6DRY_A, 6DRZ_A, 6DS0_A, 6GT3_A, 6IIU_A, 6IIV_A),
H8G/LISURIDE (6DRX_A),
P2E/DINOPROSTONE (6AK3_A, 6AK3_B),
3C0/METHSCOPOLAMINE (5YC8_A, 5ZK8_A, 5ZKC_A),
ZOT/ZOTEPINE (6A94_A, 6A94_B),
JEV/RAMELTEON (6ME9_A, 6ME9_B),
ERM/ERGOTAMINE (4IAR_A, 4IB4_A, 4NC3_A, 5TUD_A, 5TUD_D, 6BQG_A),
VIS/VISMODEGIB (5L7I_A, 5L7I_B),
TEP/THEOPHYLLINE (5MZJ_A),
H8D/METHYLERGONOVINE (6DRY_A),
TAR/TARTARIC ACID (5MZP_A, 5N2R_A, 5OLZ_A),
CFF/CAFFEINE (5MZP_A),
2GM/DIHYDROERGOTAMINE (4IAQ_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


cybC has been screened with compounds ( bioactivities). (see details)