Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

purB (P0AB89) - Overview - Molecular Target Synopsis

Protein


purB, Adenylosuccinate lyase
Enzyme Classification 4.3.2.2
UniProt P0AB89

Also Known as PUR8_ECOLI, purB

Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

2PTQ
CRYSTAL STRUCTURE OF ESCHERICHIA COLI ADENYLOSUCCINATE LYASE MUTANT H171N WITH BOUND AMP AND FUMARATE
RCSB/PDB
Inspect Structure
See all 3D Structures for purB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: purB is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project purB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For purB there are:
3 structures (5 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

purB is solved in complex with the approved drug(s):

FUM/FUMARIC ACID (2PTQ_A, 2PTQ_B),
AMP/ADENOSINE PHOSPHATE (2PTQ_A, 2PTQ_B).

(see details)
Molecular Target 3D Synopsis