Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rpoZ (P0A800) - Overview - Molecular Target Synopsis

Protein


rpoZ, DNA-directed RNA polymerase subunit omega
Enzyme Classification 2.7.7.6
UniProt P0A800

Also Known as RPOZ_ECOLI, rpoZ

Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

6N61
ESCHERICHIA COLI RNA POLYMERASE SIGMA70-HOLOENZYME BOUND TO UPSTREAM FORK PROMOTER DNA AND CAPISTRUIN
RCSB/PDB
Inspect Structure
See all 3D Structures for rpoZ

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rpoZ is active in the following subcellular-locations: cytosol, RNA polymerase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpoZ has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpoZ there are:
52 structures (75 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


rpoZ has been screened with compounds ( bioactivities). (see details)