Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rpoA (P0A7Z4) - Overview - Molecular Target Synopsis

Protein


rpoA, DNA-directed RNA polymerase subunit alpha
Enzyme Classification 2.7.7.6
UniProt P0A7Z4

Also Known as RPOA_ECOLI, rpoA, pez, phs, sez

DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme. Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. Both the N- and C-terminus interact with different regions of transcriptional regulator CRP.

6N61
ESCHERICHIA COLI RNA POLYMERASE SIGMA70-HOLOENZYME BOUND TO UPSTREAM FORK PROMOTER DNA AND CAPISTRUIN
RCSB/PDB
Inspect Structure
See all 3D Structures for rpoA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rpoA is active in the following subcellular-locations: cytoplasm, cytosol, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpoA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpoA there are:
61 structures (175 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


rpoA has been screened with compounds ( bioactivities). (see details)