Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rpsI (P0A7X3) - Overview - Molecular Target Synopsis

Protein


rpsI, 30S ribosomal protein S9
UniProt P0A7X3

Also Known as RS9_ECOLI, rpsI

The C-terminal tail plays a role in the affinity of the 30S P site for different tRNAs. Mutations that decrease this affinity are suppressed in the 70S ribosome. Part of the 30S ribosomal subunit (PubMed:1091515, PubMed:7556101, PubMed:10094780, PubMed:12809609, PubMed:16272117, PubMed:27934701, PubMed:12244297, PubMed:27906160, PubMed:27906161, PubMed:28077875). Contacts 16S rRNA (PubMed:7556101). Cross-links to the P site tRNA and weakly to the A site tRNA (PubMed:8524654, PubMed:15308780).

5NO4
RSGA-GDPNP BOUND TO THE 30S RIBOSOMAL SUBUNIT (RSGA ASSEMBLY INTERMEDIATE WITH US3)
RCSB/PDB
Inspect Structure
See all 3D Structures for rpsI

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rpsI is active in the following subcellular-locations: cytosol, cytosolic small ribosomal subunit.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpsI has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpsI there are:
9 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis