Molecular Target Synopsis
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rpsE (P0A7W1) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed11
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5U4J_e 30S ribosomal protein S5 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.53 70 14.3 No No
2 empty 2.64 61.4 17.9 No No
3 empty 1.76 63.3 12.6 No No
4 empty 1.93 71.8 10.9 No No
5 empty 2.69 64.3 12 No No
6 empty 2.19 77.8 9.5 No No
7 empty 1.94 65.3 11.4 No No
8 empty 2.28 72.6 10 No No
9 empty 1.86 65.3 7.9 No No
10 empty 2.33 69.8 7.6 No No
5ME1_E 30S ribosomal protein S5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 56.9 24.1 Yes No
2 empty 2.42 69.9 18.2 No No
3 empty 2.1 62 12.9 No No
4 empty 2.48 57.9 16.4 No No
5 empty 1.95 58.6 13.6 No No
6 empty 2.35 58.2 16.5 No No
7 empty 1.82 70.2 11.7 No No
8 empty 2.5 64.2 13.8 No No
9 empty 2.37 65.9 7.5 No No
10 empty 2.3 67.3 7.7 No No
4A2I_E 30S ribosomal protein S5 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 65.8 15.6 No No
2 empty 2.07 63.5 17.3 No No
3 empty 2.01 54.1 13.9 No No
4 empty 2.03 64.5 12.1 No No
5 empty 2.47 58.7 9.7 No No
6 empty 2.57 66.9 9 No No
7 empty 2.78 62.4 12.5 No No
8 empty 2.87 62.7 11.7 No No
9 empty 2.35 54.1 10.6 No No
10 empty 2.41 64.2 10.1 No No
5UZ4_E 30S ribosomal protein S5 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.56 59.3 23.4 No No
2 empty 2.26 65.9 14.5 No No
3 empty 2.26 62.9 16.9 No No
4 empty 2.26 56.2 13.3 No No
5 empty 2.14 64.1 10.3 No No
6 empty 1.46 77.8 9.6 No No
7 empty 1.73 62.8 13.3 No No
8 empty 2.07 69.4 11.5 No No
9 empty 2.67 60.6 10.9 No No
10 empty .54 81.2 8.4 No No
5NO4_E 30S ribosomal protein S5 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 57.3 20.5 No No
2 empty 2.16 66.5 17.7 No No
3 empty 2.14 65.5 13.6 No No
4 empty 2.46 61.8 16.7 No No
5 empty 1.75 68.5 10.3 No No
6 empty 2.33 57.1 16.8 No No
7 empty 2.18 69.6 13.3 No No
8 empty 2.61 58.3 12.6 No No
9 empty 2.59 73.7 11.8 No No
10 empty 2.37 62.9 13.6 No No
5MY1_E 30S ribosomal protein S5 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 67.6 16.9 No No
2 empty 2.1 66.7 16.7 No No
3 empty 2.36 58.8 19.4 No No
4 empty 2.02 67.9 14.4 No No
5 empty 2.47 56.4 10.7 No No
6 empty 2.81 65.7 10.8 No No
7 empty 2.74 64.6 12.1 No No
8 empty 2.2 54.4 11.2 No No
9 empty 2.76 60.2 11.5 No No
10 empty 2.51 54.1 9.5 No No
4ADV_E 30S ribosomal protein S5 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 67.5 17.6 No No
2 empty 2.44 58.4 20 No No
3 empty 2.11 65 17.5 No No
4 empty 2.43 53.7 11.7 No No
5 empty 1.99 66.2 15.2 No No
6 empty 2.93 62.8 11.4 No No
7 empty 2.18 56.7 11.7 No No
8 empty 1.84 65 13.3 No No
9 empty 2.96 58.1 14 No No
10 empty 3.14 60.4 10.1 No No
5NO3_E 30S ribosomal protein S5 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 58.2 21.7 No No
2 empty 2.36 69.4 16 No No
3 empty 2.1 67.4 12.5 No No
4 empty 1.72 69.4 10.7 No No
5 empty 2.55 61.4 16.4 No No
6 empty 2.04 66.4 13.9 No No
7 empty 2.16 57.6 16.8 No No
8 empty 2.6 59.6 12.6 No No
9 empty 2.4 62.6 15 No No
10 empty 2.67 74.3 9.2 No No
2YKR_E 30S ribosomal protein S5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 64 26.7 Yes No
2 empty 2.05 54.2 19.6 No No
3 empty 1.81 54.9 16.7 No No
4 empty 1.79 60 15.8 No No
5 empty 2.15 67.7 10.9 No No
6 empty 1.75 55.7 10.1 No No
7 empty 1.52 98.6 0 Yes No
8 empty 2.91 66.1 5.2 No No
9 empty 2.8 76.3 6.5 No No
10 empty 3.08 72.6 6.5 No No
5ME0_E 30S ribosomal protein S5 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 57.1 18.1 No No
2 empty 2.45 70.4 15.7 No No
3 empty 2.08 62.1 15.2 No No
4 empty 2.1 62.3 12.8 No No
5 empty 2.09 66.8 14.2 No No
6 empty 2.49 51.8 16 No No
7 empty 1.93 61.3 14.8 No No
8 empty 2.22 59.4 16.1 No No
9 empty 2.4 60.7 10.7 No No
10 empty 2.34 66.7 7.5 No No
5NO2_E 30S ribosomal protein S5 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 57.9 21.7 No No
2 empty 2.28 66.9 19.1 No No
3 empty 2.46 62 16.6 No No
4 empty 1.72 69.5 9.9 No No
5 empty 2.13 63.4 14.7 No No
6 empty 2.14 66.8 14.4 No No
7 empty 2.3 59.1 16.8 No No
8 empty 2.61 59.8 12.4 No No
9 empty 2.67 74.2 9.2 No No
10 empty 2.38 65.1 15 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed78
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria17

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1VS5_E (144439) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.46Å No No
1VS5_E (144440) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.46Å No No
1VS7_E (144480) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.46Å No No
1VS7_E (144481) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.46Å No No
2AVY_E (144846) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.46Å No No
2AVY_E (144847) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.46Å No No
2AW7_E (144889) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.46Å No No
2AW7_E (144890) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.46Å No No
2I2P_E (145424) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.2Å No No
2I2P_E (145425) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.2Å No No
2I2U_E (145466) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.2Å No No
2I2U_E (145467) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.2Å Yes No
2QAL_E (150217) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.21Å Yes No
2QAL_E (150218) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.21Å No No
2QAN_E (150271) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.21Å Yes No
2QAN_E (150272) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.21Å No No
2QB9_E (150332) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.54Å No No
2QB9_E (150331) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.54Å Yes No
2QBB_E (150384) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.54Å Yes No
2QBB_E (150385) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.54Å No No
2QBD_E (150437) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.3Å No No
2QBD_E (150438) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.3Å No No
2QBF_E (150491) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.3Å No No
2QBF_E (150492) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.3Å No No
2QBH_E (150546) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 4Å No No
2QBH_E (150545) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 4Å Yes No
2QBJ_E (150599) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 4Å Yes No
2QBJ_E (150600) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 4Å No No
2QOU_E (150988) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.93Å No No
2QOU_E (150989) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.93Å No No
2QOW_E (151041) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.93Å No No
2QOW_E (151042) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.93Å No No
2QOY_E (151094) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.5Å No No
2QOY_E (151095) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.5Å No No
2QP0_E (151147) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.5Å No No
2QP0_E (151148) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.5Å No No
2VHO_E (153126) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.74Å No No
2VHO_E (153127) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.74Å No No
2VHP_E (153148) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.74Å No No
2VHP_E (153149) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.74Å No No
2WWL_E (3260078) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 5.8Å No No
2WWL_E (3260079) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, UNMATCHED 5.8Å No No
2Z4K_E (154055) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 4.45Å Yes No
2Z4K_E (154056) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 4.45Å No No
2Z4M_E (154109) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 4.45Å No No
2Z4M_E (154110) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 4.45Å No No
3DF1_E (157607) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.5Å No No
3DF1_E (157606) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.5Å No No
3DF3_E (157660) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, Translational machinery components 3.5Å No No
3DF3_E (157661) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.5Å No No
3FIH_E (3410165) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 6.7Å No No
3FIH_E (3410166) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, UNMATCHED 6.7Å Yes No
3I1M_E (4191319) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3I1M 3.19Å No No
3I1O_E (4118403) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3I1O 3.19Å No No
3I1Q_E (4202803) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3I1Q 3.8Å Yes No
3I1S_E (4093898) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3I1S 3.8Å Yes No
3I1Z_E (4002595) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3I1Z 3.7Å No No
3I21_E (4168541) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3I21 3.7Å No No
3IZV_I (3620473) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 13.2Å No No
3IZV_I (3620474) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, UNMATCHED 13.2Å No No
3IZW_I (3620502) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, UNMATCHED 8.25Å Yes No
3IZW_I (3620501) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 8.25Å No No
3KC4_E (3500308) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, UNMATCHED 9.6Å No No
3KC4_E (3500307) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 9.6Å No No
3OAQ_E (3650088) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, UNMATCHED 3.25Å No No
3OAQ_E (3650087) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.25Å No No
3OAR_E (3650110) 30S ribosomal protein S5 Ribosomal protein S5 domain 2-like, Ribosomal protein S5 domain 2-like, UNMATCHED 3.25Å No No
3OAR_E (3650109) 30S ribosomal protein S5 dsRBD-like, dsRNA-binding domain-like, Ribosomal S5 protein N-terminal domain 3.25Å No No
3OFA_E (4107312) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3OFA 3.19Å No No
3OFB_E (4119983) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3OFB 3.19Å No No
3OFO_E (4043269) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3OFO 3.1Å No No
3OFP_E (4241447) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3OFP 3.1Å Yes No
3OFX_E (4118821) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3OFX 3.289Å Yes No
3OFY_E (4006351) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3OFY 3.289Å Yes No
3OR9_E (4224954) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3OR9 3Å No No
3ORA_E (4201801) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3ORA 3Å Yes No
3R8N_E (4128231) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3R8N 3Å No No
3R8O_E (4109745) 30S ribosomal protein S5 UNMATCHED, UNMATCHED, UNMATCHED 3R8O 3Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score