Molecular Target Synopsis
Overview
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Ligand Efficiency Plot
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rpsS (P0A7U3) - Overview - Molecular Target Synopsis

Protein


rpsS, 30S ribosomal protein S19
UniProt P0A7U3

Also Known as RS19_ECOLI, rpsS

In the E.coli 70S ribosome in the initiation state (PubMed:12809609) it has been modeled to contact the 23S rRNA of the 50S subunit forming part of bridge B1a; this bridge is broken in the model with bound EF-G. The 23S rRNA contact site in bridge B1a is modeled to differ in different ribosomal states (PubMed:12859903), contacting alternately S13 or S19. In the 3.5 angstroms resolved ribosome structures (PubMed:16272117) the contacts between L5, S13 and S19 bridge B1b are different, confirming the dynamic nature of this interaction. Bridge B1a is not visible in the crystallized ribosomes due to 23S rRNA disorder., Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. Contacts the A site tRNA. Part of the 30S ribosomal subunit (PubMed:348496, PubMed:3279034, PubMed:10094780, PubMed:12244297, PubMed:12809609, PubMed:12859903, PubMed:16272117, PubMed:27934701, PubMed:27906160, PubMed:27906161). Binds S13 and L5 and cross-links to the A site tRNA (PubMed:12809609, PubMed:16272117, PubMed:12859903).

5NO3
RSGA-GDPNP BOUND TO THE 30S RIBOSOMAL SUBUNIT (RSGA ASSEMBLY INTERMEDIATE WITHOUT US3)
RCSB/PDB
Inspect Structure
See all 3D Structures for rpsS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rpsS is active in the following subcellular-locations: cytosol, cytosolic small ribosomal subunit.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpsS has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpsS there are:
10 structures (10 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis