Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rpsR (P0A7T7) - Overview - Molecular Target Synopsis

Protein


rpsR, 30S ribosomal protein S18
UniProt P0A7T7

Also Known as RS18_ECOLI, rpsR

Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. Part of the 30S ribosomal subunit (PubMed:776663, PubMed:7556101, PubMed:10094780, PubMed:12244297, PubMed:12809609, PubMed:16272117, PubMed:27934701, PubMed:27906160, PubMed:27906161). Forms a tight heterodimer with protein S6.

5NO4
RSGA-GDPNP BOUND TO THE 30S RIBOSOMAL SUBUNIT (RSGA ASSEMBLY INTERMEDIATE WITH US3)
RCSB/PDB
Inspect Structure
See all 3D Structures for rpsR

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rpsR is active in the following subcellular-locations: cytosol, cytosolic small ribosomal subunit.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpsR has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpsR there are:
9 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


rpsR has been screened with 4 compounds (5 bioactivities). (see details)