Molecular Target Synopsis
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rpsL (P0A7S3) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed10
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria9


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5ME1_L 30S ribosomal protein S12 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 58 29 Yes No
2 empty 2.19 56 19 No No
3 empty 2.28 59.4 15.4 No No
4 empty 2.4 48.1 14.8 No No
5 empty 2.05 55.9 15.2 No No
6 empty 2.33 64.3 13.8 No No
7 empty 2.84 64.5 9.5 No No
8 empty 2.81 56.9 12.8 No No
9 empty 2.25 67 9.8 No No
10 empty 2.41 39.9 12 No No
3J0D_I 30S ribosomal protein S12 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 59 29 Yes No
2 empty 2.34 75.6 11.3 No No
3 empty 1.71 65.7 13.7 No No
4 empty 2.76 59.9 10.6 No No
5 empty 1.64 46.9 11.1 No No
6 empty 2.65 52 8.6 No No
7 empty 2.78 71.8 8.5 No No
8 empty 1.27 56.8 8.1 No No
9 empty 2.93 49 7.3 No No
10 empty 2.05 57.6 8.7 No No
4ADV_L 30S ribosomal protein S12 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 60.4 29.3 Yes No
2 empty 2.22 64.7 16.7 No No
3 empty 2.22 51.7 18.2 No No
4 empty 2.13 69.9 11.2 No No
5 empty 2.79 64.4 9.8 No No
6 empty 2.79 53.7 9.7 No No
7 empty 2.73 57.6 8.4 No No
8 empty 2.96 55 8.5 No No
9 empty 2.41 57.5 6.5 No No
10 empty 2 53.4 8.7 No No
5ME0_L 30S ribosomal protein S12 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 57.9 31 Yes No
2 empty 2.33 59.9 15 No No
3 empty 2 53.1 15.4 No No
4 empty 2.43 48.9 14.7 No No
5 empty 2.32 67.1 14.5 No No
6 bound 2.43 76.3 14.3 No No
7 empty 2.64 63.2 9.9 No No
8 empty 2.49 44.7 12.1 No No
9 empty 3.03 56.6 11.8 No No
10 empty 2.1 66.3 9.6 No No
2YKR_L 30S ribosomal protein S12 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 65.4 24.1 Yes No
2 empty 2.12 62.6 31.6 No No
3 empty 2.42 52.1 28.7 No No
4 empty 1.98 73.8 14.6 No No
5 empty 2.9 63 6.8 No No
6 empty 2.41 61.4 9.1 No No
7 empty 2.2 64.4 7.3 No No
8 empty 1.98 68 5.6 No No
9 empty 2.56 71.8 5.9 No No
10 empty 2.7 62.2 6.5 No No
3J0E_F 30S ribosomal protein S12 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 58.6 29.4 Yes No
2 empty 2.13 49.8 19.4 No No
3 empty 2.22 72 11.5 No No
4 empty 1.73 71.8 10.3 No No
5 empty 2.71 57.5 10.8 No No
6 empty 2.7 63.4 9.4 No No
7 empty 2.88 53.1 7.7 No No
8 empty 1.85 58.9 8.3 No No
9 empty 2.25 68 7.1 No No
10 empty 2.95 70.1 5.6 No No
3DEG_D 30S ribosomal protein S12 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 57.1 30.9 Yes No
2 empty 1.95 66 12.5 No No
3 empty 2.2 45.9 18.2 No No
4 empty 2.73 48.5 10.5 No No
5 empty 2.59 47.9 12.7 No No
6 empty 2.75 65.4 11 No No
7 empty 1.66 71.5 10.4 No No
8 empty 1.98 49 8.1 No No
9 empty 2.54 61.7 8.1 No No
10 empty 2.55 64.3 8.1 No No
4A2I_L 30S ribosomal protein S12 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 59.6 29.4 Yes No
2 empty 2.08 61.8 16.4 No No
3 empty 2.12 47.6 18.7 No No
4 empty 1.64 64.2 13.3 No No
5 empty 2.65 58.1 13.2 No No
6 empty 2.65 72.8 9 No No
7 empty 2.64 52.8 8.7 No No
8 empty 3.24 67.6 6.4 No No
9 empty 2.68 54.7 9.2 No No
10 empty 2.12 58.2 6.2 No No
5U4J_l 30S ribosomal protein S12 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 56.9 21.9 No No
2 empty 2.4 64.3 22.7 No No
3 empty 1.76 53.1 15.6 No No
4 empty 2.26 59.7 11.5 No No
5 empty 2.23 65 10.5 No No
6 empty 2.63 58.4 13.7 No No
7 empty 2.92 56.3 14.7 No No
8 empty 2.61 50.2 13.6 No No
9 empty 2.84 64.1 10.2 No No
10 empty 2.66 75.4 7.1 No No
5MY1_L 30S ribosomal protein S12 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 58.7 29.9 Yes No
2 empty 2.33 73.1 10.4 No No
3 empty 1.43 66.2 9.5 No No
4 empty 2.73 57.8 11.2 No No
5 empty 1.63 50.2 11.6 No No
6 empty 2.6 50 8.7 No No
7 empty 2.73 65.5 9 No No
8 empty 2.86 54.1 9.9 No No
9 empty 1.88 43.9 8.4 No No
10 empty 2.26 72.2 7.1 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed48
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria45

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1VS5_L (144446) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.46Å Yes No
1VS7_L (144487) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.46Å Yes No
2AVY_L (144853) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.46Å Yes No
2AW7_L (144896) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.46Å Yes No
2I2P_L (145431) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.2Å Yes No
2I2U_L (145473) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.2Å Yes No
2QAL_L (150225) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.21Å Yes No
2QAN_L (150279) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.21Å Yes No
2QB9_L (150339) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.54Å Yes No
2QBB_L (150392) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.54Å Yes No
2QBD_L (150445) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.3Å Yes No
2QBF_L (150499) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.3Å Yes No
2QBH_L (150553) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 4Å Yes No
2QBJ_L (150607) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 4Å Yes No
2QOU_L (150996) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.93Å Yes No
2QOW_L (151049) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.93Å Yes No
2QOY_L (151102) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.5Å Yes No
2QP0_L (151155) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.5Å Yes No
2VHO_L (153134) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.74Å Yes No
2VHP_L (153156) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.74Å Yes No
2WWL_L (3260086) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, UNMATCHED 5.8Å No No
2Z4K_L (154063) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 4.45Å Yes No
2Z4M_L (154117) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 4.45Å Yes No
3DEG_D (157573) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 10.9Å Yes No
3DF1_L (157614) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.5Å Yes No
3DF3_L (157668) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, Cold shock DNA-binding domain-like 3.5Å Yes No
3FIH_L (3410173) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, UNMATCHED 6.7Å Yes No
3I1M_L (4191331) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3I1M 3.19Å Yes No
3I1O_L (4118415) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3I1O 3.19Å Yes No
3I1Q_L (4202815) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3I1Q 3.8Å Yes No
3I1S_L (4093910) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3I1S 3.8Å Yes No
3I1Z_L (4002599) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3I1Z 3.7Å Yes No
3I21_L (4168553) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3I21 3.7Å Yes No
3IZV_P (3620483) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, UNMATCHED 13.2Å No No
3IZW_P (3620511) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, UNMATCHED 8.25Å Yes No
3KC4_L (3500317) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, UNMATCHED 9.6Å No No
3OAQ_L (3650095) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, UNMATCHED 3.25Å Yes No
3OAR_L (3650117) 30S ribosomal protein S12 OB-fold, Nucleic acid-binding proteins, UNMATCHED 3.25Å Yes No
3OFA_L (4107324) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3OFA 3.19Å Yes No
3OFB_L (4119995) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3OFB 3.19Å Yes No
3OFO_L (4043281) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3OFO 3.1Å Yes No
3OFP_L (4241459) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3OFP 3.1Å Yes No
3OFX_L (4118833) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3OFX 3.289Å Yes No
3OFY_L (4006355) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3OFY 3.289Å Yes No
3OR9_L (4224966) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3OR9 3Å Yes No
3ORA_L (4201813) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3ORA 3Å Yes No
3R8N_L (4128243) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3R8N 3Å Yes No
3R8O_L (4109757) 30S ribosomal protein S12 UNMATCHED, UNMATCHED, UNMATCHED 3R8O 3Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score