Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

rpsJ (P0A7R5) - Overview - Molecular Target Synopsis

Protein


rpsJ, 30S ribosomal protein S10
UniProt P0A7R5

Also Known as RS10_ECOLI, rpsJ, nusE

Involved in the binding of tRNA to the ribosomes (PubMed:6759118). In addition, in complex with NusB, is involved in the regulation of ribosomal RNA (rRNA) biosynthesis by transcriptional antitermination. S10 binds RNA non-specifically and increases the affinity of NusB for the boxA RNA sequence (PubMed:7678781, PubMed:11884128, PubMed:16109710). S10 may constitute the critical antitermination component of the NusB-S10 complex (PubMed:19111659). Part of the 30S ribosomal subunit (PubMed:10094780, PubMed:12244297, PubMed:12809609, PubMed:16272117, PubMed:27906160, PubMed:27906161, PubMed:27934701, PubMed:28077875, PubMed:7007073). Can also form a heterodimer with the transcription antitermination protein NusB (PubMed:1731086, PubMed:11884128, PubMed:16109710, PubMed:19111659). Binding of S10 to NusB is mutually exclusive with its incorporation into the ribosome (PubMed:19111659).

5NO4
RSGA-GDPNP BOUND TO THE 30S RIBOSOMAL SUBUNIT (RSGA ASSEMBLY INTERMEDIATE WITH US3)
RCSB/PDB
Inspect Structure
See all 3D Structures for rpsJ

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rpsJ is active in the following subcellular-locations: cytosol, cytosolic small ribosomal subunit.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpsJ has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpsJ there are:
16 structures (20 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis