Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

prfC (P0A7I4) - Overview - Molecular Target Synopsis

Protein


prfC, Peptide chain release factor RF3
UniProt P0A7I4

Also Known as RF3_ECOLI, prfC, miaD, tos

Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

2O0F
DOCKING OF THE MODIFIED RF3 X-RAY STRUCTURE INTO CRYO-EM MAP OF E.COLI 70S RIBOSOME BOUND WITH RF3
RCSB/PDB
Inspect Structure
See all 3D Structures for prfC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: prfC is active in the following subcellular-locations: cytoplasm.
GO terms: prfC is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project prfC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For prfC there are:
2 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis