Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pyrI (P0A7F3) - Overview - Molecular Target Synopsis

Protein


pyrI, Aspartate carbamoyltransferase regulatory chain
UniProt P0A7F3

Also Known as PYRI_ECOLI, pyrI

Involved in allosteric regulation of aspartate carbamoyltransferase. Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

4FYW
E. COLI ASPARTATE TRANSCARBAMOYLASE COMPLEXED WITH CTP
RCSB/PDB
Inspect Structure
See all 3D Structures for pyrI

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: pyrI is active in the following subcellular-locations: aspartate carbamoyltransferase complex, cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project pyrI has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pyrI there are:
54 structures (119 chains) solved
25 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis