Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pyrB (P0A786) - Overview - Molecular Target Synopsis

Protein


pyrB, Aspartate carbamoyltransferase catalytic subunit
Enzyme Classification 2.1.3.2
UniProt P0A786

Also Known as PYRB_ECOLI, pyrB

Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

4FYY
E. COLI ASPARTATE TRANSCARBAMOYLASE COMPLEXED WITH CTP, UTP, AND MG2+
RCSB/PDB
Inspect Structure
See all 3D Structures for pyrB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: pyrB is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project pyrB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pyrB there are:
57 structures (126 chains) solved
27 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


pyrB has been screened with compounds ( bioactivities). (see details)