Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

dnaK (P0A6Y8) - Overview - Molecular Target Synopsis

Protein


dnaK, Chaperone protein DnaK
UniProt P0A6Y8

Also Known as DNAK_ECOLI, dnaK, groP, grpF, seg

Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.

5OOW
CRYSTAL STRUCTURE OF LOBE II FROM THE NUCLEOTIDE BINDING DOMAIN OF DNAK IN COMPLEX WITH AMPPCP
RCSB/PDB
Inspect Structure
See all 3D Structures for dnaK

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: dnaK is active in the following subcellular-locations: cell inner membrane, cytoplasm.
GO terms: dnaK is active in the following subcellular-locations: cytoplasm, cytosol, membrane, plasma membrane, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project dnaK has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For dnaK there are:
46 structures (83 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


dnaK has been screened with compounds ( bioactivities). (see details)