Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

tsf (P0A6P3) - Overview - Molecular Target Synopsis

Protein


tsf, Elongation factor Ts
UniProt P0A6P3

Also Known as EFTS_ECO57, tsf

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Heterotetramer composed of two EF-Ts.EF-Tu dimer complexes.

3VNV
COMPLEX STRUCTURE OF VIRAL RNA POLYMERASE II
RCSB/PDB
Inspect Structure
See all 3D Structures for tsf

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: tsf is active in the following subcellular-locations: cytoplasm.
GO terms: tsf is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project tsf has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For tsf there are:
11 structures (11 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis