Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

tufA,tufB (P0A6N3) - Overview - Molecular Target Synopsis

Protein


tufA,tufB, Elongation factor Tu
UniProt P0A6N3

Also Known as EFTU_ECO57, tufA,tufB

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis., May play an important regulatory role in cell growth and in the bacterial response to nutrient deprivation. Monomer.

3VNV
COMPLEX STRUCTURE OF VIRAL RNA POLYMERASE II
RCSB/PDB
Inspect Structure
See all 3D Structures for tufA,tufB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: tufA,tufB is active in the following subcellular-locations: cell inner membrane, cytoplasm.
GO terms: tufA,tufB is active in the following subcellular-locations: cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project tufA,tufB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For tufA,tufB there are:
11 structures (11 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis