Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

nanA (P0A6L4) - Overview - Molecular Target Synopsis

Protein


nanA, N-acetylneuraminate lyase
Enzyme Classification 4.1.3.3
UniProt P0A6L4

Also Known as NANA_ECOLI, nanA, npl

Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. Homotetramer.

4UUI
A CASE STUDY FOR TWINNED DATA ANALYSIS: MULTIPLE CRYSTAL FORMS OF THE ENZYME N-ACETYL-NEURAMINIC LYASE
RCSB/PDB
Inspect Structure
See all 3D Structures for nanA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: nanA is active in the following subcellular-locations: cytoplasm.
GO terms: nanA is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project nanA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


nanA was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For nanA there are:
23 structures (92 chains) solved
11 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis