dapA, 4-hydroxy-tetrahydrodipicolinate synthase
Enzyme Classification 22.214.171.124
Also Known as
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). Homotetramer; dimer of dimers.
Isoforms / Transcripts (Protein Coding)
UniProt: dapA is active in the following subcellular-locations: cytoplasm.
GO terms: dapA is active in the following subcellular-locations: cytosol.
Gene Copy Number Variation
In COSMIC - Cell Lines Project dapA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)
Screening and Chemistry
dapA has been screened with 9 compounds (24 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)