Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

dapA (P0A6L2) - Overview - Molecular Target Synopsis

Protein


dapA, 4-hydroxy-tetrahydrodipicolinate synthase
Enzyme Classification 4.3.3.7
UniProt P0A6L2

Also Known as DAPA_ECOLI, dapA

Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). Homotetramer; dimer of dimers.

4EOU
CRYSTAL STRUCTURE OF E. COLI DIHYDRODIPICOLINATE SYNTHASE WITH PYRUVATE AND SUCCINIC SEMI-ALDEHYDE BOUND IN ACTIVE SITE
RCSB/PDB
Inspect Structure
See all 3D Structures for dapA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
292P0A6L2-1, B7M7I1-1, B1IWI1-1, P0A6L3-1

Sub-cellular localization


UniProt: dapA is active in the following subcellular-locations: cytoplasm.
GO terms: dapA is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project dapA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For dapA there are:
18 structures (36 chains) solved
8 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


dapA has been screened with 9 compounds (24 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)