Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

dhaA (P0A3G2) - Overview - Molecular Target Synopsis

Protein


dhaA, Haloalkane dehalogenase
Enzyme Classification 3.8.1.5
UniProt P0A3G2

Also Known as DHAA_RHORH, dhaA

Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Expresses halogenase activity against 1-chloroalkanes of chain length C3 to C10, and also shows a very weak activity with 1,2-dichloroethane. Monomer.

5VNP
X-RAY CRYSTAL STRUCTURE OF HALOTAG BOUND TO THE P1 BENZOXADIAZOLE FLUOROGENIC LIGAND
RCSB/PDB
Inspect Structure
See all 3D Structures for dhaA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
293P0A3G2-1, P0A3G3-1, P0A3G4-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project dhaA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For dhaA there are:
13 structures (16 chains) solved
6 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

dhaA is solved in complex with the approved drug(s):

BEZ/BENZOIC ACID (3FBW_A, 4F5Z_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


dhaA has been screened with compounds ( bioactivities). (see details)