Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

glnA (P0A1P6) - Overview - Molecular Target Synopsis

Protein


glnA, Glutamine synthetase
Enzyme Classification 6.3.1.2
UniProt P0A1P6

Also Known as GLN1B_SALTY, glnA

Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Oligomer of 12 subunits arranged in the form of two hexameric ring.

1F1H
CRYSTAL STRUCTURE OF GLUTAMINE SYNTHETASE FROM SALMONELLA TYPHIMURIUM WITH THALLIUM IONS
RCSB/PDB
Inspect Structure
See all 3D Structures for glnA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: glnA is active in the following subcellular-locations: cytoplasm.
GO terms: glnA is active in the following subcellular-locations: cytoplasm, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project glnA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For glnA there are:
6 structures (72 chains) solved
5 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

glnA is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (1LGR_A, 1LGR_B, 1LGR_C, 1LGR_D, 1LGR_E, 1LGR_F, 1LGR_G, 1LGR_H, 1LGR_I, 1LGR_J, 1LGR_K, 1LGR_L).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


glnA has been screened with 1 compounds (1 bioactivities). (see details)