Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

udp (P0A1F6) - Overview - Molecular Target Synopsis

Protein


udp, Uridine phosphorylase
Enzyme Classification 2.4.2.3
UniProt P0A1F6

Also Known as UDP_SALTY, udp

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Homohexamer.

4OGK
X-RAY STRUCTURE OF THE URIDINE PHOSPHORYLASE FROM SALMONELLA TYPHIMURIUM IN COMPLEX WITH THYMIDINE AT 2.40 A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for udp

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
253P0A1F6-1, P0A1F7-1

Sub-cellular localization


UniProt: udp is active in the following subcellular-locations: cytoplasm.
GO terms: udp is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project udp has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For udp there are:
24 structures (127 chains) solved
14 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

udp is solved in complex with the approved drug(s):

URF/FLUOROURACIL (4E1V_A, 4E1V_B, 4E1V_C, 4E1V_D, 4E1V_E, 4E1V_F, 4E1V_G, 4E1V_H).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


udp has been screened with compounds ( bioactivities). (see details)