Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

doxB (P0A111) - Overview - Molecular Target Synopsis

Protein


doxB, Naphthalene 1,2-dioxygenase system, large oxygenase component
Enzyme Classification 1.14.12.12
UniProt P0A111

Also Known as NDOB_PSEU8, doxB

Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. The alpha subunit has a catalytic role in the holoenzyme. The naphthalene dioxygenase (NDO) multicomponent enzyme system is composed of an electron transfer component and a dioxygenase component (iron sulfur protein (ISP)). The electron transfer component is composed of a ferredoxin reductase and a ferredoxin (DoxA), and the dioxygenase component is formed of a heterohexamer (trimer of heterodimers) of three large alpha subunits (DoxB) and three small beta subunits (DoxD).

4HM0
NAPHTHALENE 1,2-DIOXYGENASE BOUND TO INDOLE-3-ACETATE
RCSB/PDB
Inspect Structure
See all 3D Structures for doxB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Gene Copy Number Variation


In COSMIC - Cell Lines Project doxB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For doxB there are:
17 structures (17 chains) solved
16 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis