Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

doxB (P0A111) - Overview - Molecular Target Synopsis


doxB, Naphthalene 1,2-dioxygenase system, large oxygenase component
Enzyme Classification
UniProt P0A111

Also Known as NDOB_PSEU8, doxB

Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. The alpha subunit has a catalytic role in the holoenzyme. The naphthalene dioxygenase (NDO) multicomponent enzyme system is composed of an electron transfer component and a dioxygenase component (iron sulfur protein (ISP)). The electron transfer component is composed of a ferredoxin reductase and a ferredoxin (DoxA), and the dioxygenase component is formed of a heterohexamer (trimer of heterodimers) of three large alpha subunits (DoxB) and three small beta subunits (DoxD).

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Gene Copy Number Variation

In COSMIC - Cell Lines Project doxB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures

For doxB there are:
17 structures (17 chains) solved
16 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis