Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CPB1 (P09955) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/04/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/04/2019)


Chains assessed79
Chains with at least one site assessed as druggable using the strict criteria22
Chains with at least one site assessed as druggable using the relaxed criteria76


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2PJ9_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 77.6 18.2 Yes No
2 empty 2.04 66.4 26 No No
3 empty 2.5 62.4 31.7 No No
4 empty 2.27 56.2 13.8 No No
5 empty 2.26 67.4 16.8 No No
6 empty 2.57 67.9 9.5 No No
7 empty 2.17 65.3 17.2 No No
8 empty 2.12 66.7 9.9 No No
9 empty 1.85 68.2 10.6 No No
10 empty 2.36 71 10.3 No No
5LRJ_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 76.7 23.6 Yes No
2 empty 2.15 66.1 29.9 No No
3 empty 2.53 67.2 27.1 No No
4 empty 2.27 59.1 15.1 No No
5 empty 2.21 60.6 17.2 No No
6 empty 2.11 66 20.8 No No
7 empty 2.36 68.8 15.2 No No
8 empty 2.42 69.8 12.2 No No
9 empty 2.09 55.8 10.9 No No
10 empty 2.54 62.2 11.3 No No
1ZG8_A Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 80.6 16.9 Yes Yes
2 empty 1.99 67 16.3 No No
3 empty 2.52 62.8 17.1 No No
4 empty 1.89 59 15.5 No No
5 empty 2.27 70.6 9.4 No No
6 empty 1.92 64.6 20.8 No No
7 empty 2.1 70 13.5 No No
8 empty 2.34 67.9 9.4 No No
9 empty 2.46 68.3 10 No No
10 empty 2.49 64.7 12.5 No No
2PIY_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 77.5 18.1 Yes No
2 empty 2.15 67 20.8 No No
3 empty 2.47 70.4 24.1 No No
4 empty 2.27 57.7 13.5 No No
5 empty 2.18 61.6 12.3 No No
6 empty 1.99 69.3 20 No No
7 empty 2.43 69.3 21.3 No No
8 empty 2.39 70.6 15.1 No No
9 empty 2.46 67 14 No No
10 empty 2.25 60.8 13.7 No No
5LYI_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 75.6 16.6 Yes No
2 empty 2.51 68.8 25.6 No No
3 empty 1.92 68 16 No No
4 empty 2.21 65 17.5 No No
5 empty 2.36 60.6 13 No No
6 empty 2.24 62 13.1 No No
7 empty 2.45 64.7 12.6 No No
8 empty 1.93 68.8 11.9 No No
9 empty 2.08 56.1 11.6 No No
10 empty 2.43 70.6 7.8 No No
2PJA_A Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 79.5 18.6 Yes Yes
2 empty 2.41 69.1 31.5 No No
3 empty 1.94 71.1 15.9 No No
4 empty 2.22 67.4 15.8 No No
5 empty 2.46 73.4 14.4 No No
6 empty 2.06 67.9 18.1 No No
7 empty 1.99 60.9 15.2 No No
8 empty 2.11 62.5 10.3 No No
9 empty 2.33 57.7 10.5 No No
10 empty 2.2 61.1 9.3 No No
1ZG8_C Carboxypeptidase B No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 67.9 23.8 No No
2 bound 1.97 78.2 20.1 No No
3 empty 2.2 69.6 20.7 No No
4 empty 2.4 67.7 16.9 No No
5 empty 1.79 67.9 16.1 No No
6 empty 2.02 58.9 15 No No
7 empty 1.94 55.7 14.4 No No
8 empty 2.02 59.2 13.9 No No
9 empty 2.4 58.6 10.2 No No
10 empty 1.95 76.6 7.7 No No
2PJ3_A Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 79.4 20.8 Yes Yes
2 empty 1.96 72.7 15.1 No No
3 empty 2.39 62.2 17.7 No No
4 empty 2.19 68.6 13.4 No No
5 empty 2.04 65.3 19.2 No No
6 empty 2.03 59 15.8 No No
7 empty 2.38 67.1 8.3 No No
8 empty 2.09 60.6 9.9 No No
9 empty 2.47 59.1 10.3 No No
10 empty 2.6 70.4 10.1 No No
5LRK_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 74.9 22.5 Yes No
2 empty 2 67.9 24.9 No No
3 empty 2.3 58.5 14.1 No No
4 empty 2.8 66.4 23.4 No No
5 empty 2.5 67.2 16.6 No No
6 empty 2.11 67.3 20.8 No No
7 empty 2.09 64.2 16.3 No No
8 empty 2.11 67.5 14 No No
9 empty 2.47 68.9 12.1 No No
10 empty 2.14 54.5 9.9 No No
5ZEQ_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 76.6 17.6 Yes No
2 empty 2.07 62.7 26.5 No No
3 empty 1.84 66.7 17.8 No No
4 empty 2.31 70.4 21.8 No No
5 empty 2.26 65.7 18.3 No No
6 empty 2.14 58.1 16 No No
7 empty 2.36 70.8 9.7 No No
8 empty 2.16 70.2 16.8 No No
9 empty 2.51 63.8 15.3 No No
10 empty 2.53 60.6 12.5 No No
4UIA_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 76.9 20.3 Yes No
2 empty 2.33 65 20 No No
3 empty 2.62 65 21.3 No No
4 empty 1.93 67.2 17.5 No No
5 empty 2.34 69.5 9.4 No No
6 empty 2.37 60.1 13.3 No No
7 empty 2.06 72.6 13.8 No No
8 empty 1.98 60.3 15.3 No No
9 empty 2.17 62.4 12.4 No No
10 empty 1.65 53.8 14.1 No No
1Z5R_B Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.66 79.8 15.7 Yes Yes
2 empty 1.97 68.5 25.2 No No
3 empty 2.39 66.1 21.5 No No
4 empty 2.5 62.2 18.1 No No
5 empty 2.08 67.7 14 No No
6 empty 1.98 70.4 17.8 No No
7 empty 2.47 59.6 14.5 No No
8 empty 2.49 68.9 14.8 No No
9 empty 1.88 58.4 16.2 No No
10 empty 2.15 56.4 14.2 No No
2PJ4_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 76 19.9 Yes No
2 empty 2.02 67.2 16.3 No No
3 empty 2.55 64.8 21.1 No No
4 empty 2.3 68.2 17.8 No No
5 empty 2.03 66.9 19.3 No No
6 empty 2.37 63.7 13.9 No No
7 empty 2.04 70 10.3 No No
8 empty 2.11 58.9 17.4 No No
9 empty 1.87 53.5 12.7 No No
10 empty 2.44 64 12.6 No No
2PJ1_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 78.1 18.4 Yes No
2 empty 2.51 62.9 19.4 No No
3 empty 1.97 73.6 15.5 No No
4 empty 2.68 68 15.3 No No
5 empty 2.16 66.4 17.6 No No
6 empty 2.46 67.8 24.2 No No
7 empty 1.95 68.9 18.3 No No
8 empty 2.01 56.6 17.2 No No
9 empty 2.09 61.8 9.9 No No
10 empty 2.46 61.1 11.7 No No
3WC5_A Carboxypeptidase B No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 62.8 23.9 No No
2 empty 2.32 60.5 28.5 No No
3 bound 1.72 75.7 18.3 No No
4 empty 2.04 68.4 18.2 No No
5 empty 2.15 65.9 13.7 No No
6 empty 2.38 70.3 21 No No
7 empty 2.25 68.5 19.1 No No
8 empty 2.59 65.6 10.6 No No
9 empty 2.51 66.1 15.4 No No
10 empty 2.11 63 13.4 No No
2PJB_B Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 72.5 19.6 Yes Yes
2 empty 2.11 68.1 23.2 No No
3 empty 2.44 62.6 16.7 No No
4 empty 2.33 66.1 16.4 No No
5 empty 1.88 56.4 16.1 No No
6 empty 2.23 58.9 15.3 No No
7 empty 1.88 67.7 15.6 No No
8 empty 2.08 65.2 16.2 No No
9 empty 2.37 59.5 19.2 No No
10 empty 2.08 57.6 11.3 No No
2PJ3_C Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 79.2 19.9 Yes Yes
2 empty 2.26 66.4 17.7 No No
3 empty 2.64 66.9 14.9 No No
4 empty 2.09 61.6 12.2 No No
5 empty 1.98 63.7 16.5 No No
6 empty 2.34 60.7 16.8 No No
7 empty 2.31 61.3 13.5 No No
8 empty 2.01 70.9 17.5 No No
9 empty 2.37 71.1 16.7 No No
10 empty 2.09 64.1 13.7 No No
2PJ1_B Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 76 18.1 Yes No
2 empty 1.94 69.2 18.6 No No
3 empty 2.48 61.2 16 No No
4 empty 2.12 63.9 17.5 No No
5 empty 1.99 68 11.9 No No
6 empty 1.73 56.8 15.1 No No
7 empty 2 68.7 13.9 No No
8 empty 2.36 60.7 13.7 No No
9 empty 2.07 58.5 11.2 No No
10 empty 2.24 60.2 16.3 No No
5LRG_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 76.2 15.8 Yes No
2 empty 1.97 66.4 26.1 No No
3 empty 2.3 60.6 16.7 No No
4 empty 2.58 61.2 19.6 No No
5 empty 2.54 64.5 17.3 No No
6 empty 2.17 61.3 17.3 No No
7 empty 2.05 66.1 20.2 No No
8 empty 2.26 68.3 16.1 No No
9 empty 2.47 69.5 11.7 No No
10 empty 2.46 66.3 11.3 No No
2PJ6_A Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 78.9 15.8 Yes Yes
2 empty 2.24 62.1 30.7 No No
3 empty 2.3 67.5 25 No No
4 empty 2.4 63.8 14 No No
5 empty 2.42 71.2 16 No No
6 empty 2.35 65.5 20.3 No No
7 empty 2.13 69.9 9.9 No No
8 empty 2.13 63.6 11.9 No No
9 empty 2.09 60.6 12.5 No No
10 empty 2.32 60 9.3 No No
3GLJ_A Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 69.3 28.9 Yes Yes
2 empty 1.81 83.9 23.8 Yes Yes
3 bound 2.35 64.5 27.1 No No
4 empty 2.25 62.4 20.7 No No
5 bound 1.96 71.7 14.2 No No
6 empty 1.76 63.7 19.3 No No
7 empty 2.34 63.9 20.4 No No
8 empty 2.51 62.4 12.9 No No
9 bound 2.35 68.2 15.5 No No
10 empty 1.96 69.8 18 No No
2PJ5_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 78.1 18.5 Yes No
2 empty 2.16 68.6 22.3 No No
3 empty 2.61 63.8 15.3 No No
4 empty 2.59 72.3 9.1 No No
5 empty 2.27 54.3 15.5 No No
6 empty 2.02 70 19 No No
7 empty 2.2 59.5 13.2 No No
8 empty 2.24 62 14.5 No No
9 empty 2.4 66.7 15.8 No No
10 empty 2.39 66 11.7 No No
2PJ3_B Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 81.3 18.2 Yes Yes
2 empty 2.06 67.5 24.9 No No
3 empty 2.32 61.6 20.8 No No
4 empty 2.15 64.2 16.6 No No
5 empty 2.04 59.2 18.9 No No
6 empty 2.31 58 14.8 No No
7 empty 2.02 68.5 17 No No
8 empty 2.06 58.4 17.1 No No
9 empty 1.89 68.4 15.2 No No
10 empty 2.36 62.1 19.2 No No
5LRJ_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 66.4 27.8 Yes No
2 empty 2.24 65.3 26.9 No No
3 empty 1.98 78.1 19.2 No No
4 empty 2.04 67.4 17.9 No No
5 empty 2.38 58.6 13.5 No No
6 empty 2.21 60.6 17.3 No No
7 empty 1.98 66.7 18.6 No No
8 empty 2.05 57 14.9 No No
9 empty 2.1 60.3 11.3 No No
10 empty 2.48 67 8.9 No No
2PJC_B Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 77.2 18 Yes No
2 empty 1.97 68.1 23.2 No No
3 empty 2.41 62.7 16.9 No No
4 empty 2.49 62.6 16.1 No No
5 empty 2.2 67.3 14.2 No No
6 empty 1.99 57.5 19.7 No No
7 empty 2.26 55.4 15.4 No No
8 empty 2 67 16.8 No No
9 empty 2.05 55 14.4 No No
10 empty 2.42 67.2 13.8 No No
2PJB_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 73.4 19 Yes No
2 empty 2.03 67.4 20.4 No No
3 empty 2.57 67.8 18.6 No No
4 empty 2.1 61.3 11.6 No No
5 empty 2.21 69 19.8 No No
6 empty 2.28 68.5 9.2 No No
7 empty 2.01 64 13.7 No No
8 empty 1.97 61 11.4 No No
9 empty 2.21 66.3 11.3 No No
10 empty 2.45 59.9 11 No No
4Z65_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 77.2 19.9 Yes No
2 empty 2.34 68.5 23.3 No No
3 empty 1.94 66.8 15.2 No No
4 empty 2.2 62.6 18 No No
5 empty 2.2 65.3 11.5 No No
6 empty 2.11 68.6 18.2 No No
7 empty 2.06 56.8 16.8 No No
8 empty 2.07 58.4 15.1 No No
9 empty 2.42 65.2 13.7 No No
10 empty 2.54 65.9 12.3 No No
5LRJ_B Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 77.7 17.7 Yes No
2 empty 2.05 67.1 23.4 No No
3 empty 2.53 63.4 16.2 No No
4 empty 2.16 60.7 17.4 No No
5 empty 2.35 63.8 19.4 No No
6 empty 2.05 68.8 21 No No
7 empty 2.12 65.4 14.5 No No
8 empty 2.18 55.1 19.9 No No
9 empty 1.96 57.8 11 No No
10 empty 2.51 59.7 11.6 No No
2PIZ_A Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 79.5 22.7 Yes Yes
2 empty 2.33 61.6 27.3 No No
3 empty 1.93 70.8 20.5 No No
4 empty 2.54 66.5 16.5 No No
5 empty 2.16 64.3 20.2 No No
6 empty 2.09 69.6 14.5 No No
7 empty 2.03 60.3 13.8 No No
8 empty 1.93 59 11.8 No No
9 empty 2.49 69.3 12.3 No No
10 empty 2.56 69.5 7.7 No No
2PJ8_B Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 76.7 17.9 Yes No
2 empty 2.41 61.5 21.2 No No
3 empty 2.1 67.5 20.3 No No
4 empty 2.3 62 16.5 No No
5 empty 1.9 54.1 16.4 No No
6 empty 2.05 57.2 14.5 No No
7 empty 2.09 67.4 18.3 No No
8 empty 2.06 68 13.1 No No
9 empty 2.23 65.3 14.7 No No
10 empty 2.23 60.6 12.7 No No
2PJA_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 75.7 18.9 Yes No
2 empty 1.95 67.5 21.5 No No
3 empty 2.11 59.3 15.2 No No
4 empty 2.58 67.9 17.3 No No
5 empty 2.29 55.4 15.1 No No
6 empty 2.33 71 14.2 No No
7 empty 2.2 63.4 13.2 No No
8 empty 2.07 67.9 19.7 No No
9 empty 2.31 71.1 9.8 No No
10 empty 2.05 64.1 15 No No
2PJ2_B Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 79.2 15.1 Yes Yes
2 empty 1.96 68.4 22.2 No No
3 empty 2.28 64.3 16.8 No No
4 empty 2.46 64.3 15 No No
5 empty 1.96 55.4 17.1 No No
6 empty 2.03 68.6 17.7 No No
7 empty 2.29 67.5 12.6 No No
8 empty 2.02 56.6 11.6 No No
9 empty 2.38 64.5 10 No No
10 empty 2.18 56.5 15.4 No No
2PJ8_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 68 34.3 Yes No
2 bound 1.87 76.7 18.2 No No
3 empty 1.93 71.4 14.7 No No
4 empty 2.42 71 8.5 No No
5 empty 2.17 67.6 16.7 No No
6 empty 1.94 67 18.1 No No
7 empty 2.06 59.1 12.9 No No
8 empty 1.98 60.1 15.3 No No
9 empty 1.75 58.4 11.5 No No
10 empty 2.17 58.9 9.7 No No
2PJ2_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 75.3 19.9 Yes No
2 empty 1.9 72.7 15 No No
3 empty 2.38 70 8.8 No No
4 empty 2.41 65.3 14.6 No No
5 empty 2.27 70 13.5 No No
6 empty 2.03 67.8 18.4 No No
7 empty 2.45 67.1 15 No No
8 empty 2.1 60 15.5 No No
9 empty 2.39 59.2 11.1 No No
10 empty 1.91 60.8 12.3 No No
5LRG_B Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 80.1 16.1 Yes Yes
2 empty 1.98 66.9 25.3 No No
3 empty 2.18 61.8 17 No No
4 empty 2.39 66.7 16.4 No No
5 empty 2.03 67.2 18.3 No No
6 empty 2.44 65.6 12.4 No No
7 empty 2.14 65.8 12.2 No No
8 empty 2.49 61.1 11 No No
9 empty 2.12 55.3 16.6 No No
10 empty 2.46 68 10.2 No No
1Z5R_A Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 81.8 17.3 Yes Yes
2 empty 2.02 70.5 15.4 No No
3 empty 2.28 67.8 14.7 No No
4 empty 2.47 65.2 16.6 No No
5 empty 2.11 65.6 17.7 No No
6 empty 2.15 67.4 18.3 No No
7 empty 2.4 68.4 14.8 No No
8 empty 1.99 60.1 15.2 No No
9 empty 2.16 58.3 10.7 No No
10 empty 2.1 59.8 9.9 No No
2PJ0_B Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 80.1 15.9 Yes Yes
2 empty 2.03 67.8 25.1 No No
3 empty 2.46 61.2 17.3 No No
4 empty 2.45 63.6 18.6 No No
5 empty 1.97 66.6 19.7 No No
6 empty 2.07 69.6 13.9 No No
7 empty 2.47 59.8 16.5 No No
8 empty 2.08 59 14.3 No No
9 empty 2.1 56.7 13.6 No No
10 empty 2.43 70.6 12.1 No No
2PJ0_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 78.4 20.3 Yes No
2 empty 2.43 64.3 31 No No
3 empty 2.08 67.4 18.5 No No
4 empty 2.43 63.7 19.4 No No
5 empty 1.99 70.3 19.9 No No
6 empty 2.09 68.1 11.5 No No
7 empty 2.08 61.6 10.3 No No
8 empty 1.94 59.5 15.4 No No
9 empty 1.72 59.5 12.9 No No
10 empty 2.47 70.4 8.7 No No
1ZG7_B Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 80.9 16.3 Yes Yes
2 empty 1.99 67.8 21.5 No No
3 empty 2.39 62.9 16.4 No No
4 empty 2.04 66.1 17.4 No No
5 empty 2.06 68 17.2 No No
6 empty 2.37 70.7 10.4 No No
7 empty 2.34 60.5 12.1 No No
8 empty 2.24 61.2 8.6 No No
9 empty 1.76 54.7 14.1 No No
10 empty 1.97 62 13.2 No No
5LYD_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 77.4 16.7 Yes No
2 empty 2.33 63.1 19.5 No No
3 empty 1.8 66 19 No No
4 empty 2.48 64.5 15.3 No No
5 empty 2 68 20.3 No No
6 empty 2.37 65.3 13.3 No No
7 empty 2.34 62 13.5 No No
8 empty 2.23 61.7 16.3 No No
9 empty 2.09 56.5 13.5 No No
10 empty 2.43 68.2 7.5 No No
2PJC_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 78 18.7 Yes No
2 empty 2.17 65.2 21.1 No No
3 empty 2.44 69.2 22 No No
4 empty 2.09 60.4 11.7 No No
5 empty 2.18 71.2 17.7 No No
6 empty 2.36 57.6 15.2 No No
7 empty 2.35 67.7 16.7 No No
8 empty 1.92 62.1 15.2 No No
9 empty 2.35 71.1 10.1 No No
10 empty 2.38 66.9 9.8 No No
2PJB_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 70.5 24.3 Yes No
2 empty 1.92 72.8 14.8 No No
3 empty 2.5 62.5 15.8 No No
4 empty 2.31 69.2 10.3 No No
5 empty 2.06 67.2 17.1 No No
6 empty 2.08 65.9 20.7 No No
7 empty 2.27 68.8 15.3 No No
8 empty 2.16 58.9 15.8 No No
9 empty 2.12 61.9 10.1 No No
10 empty 2.58 61.3 10.4 No No
3WC6_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 77.1 19.5 Yes No
2 empty 2.38 65.8 25.6 No No
3 empty 2.58 62.3 21.2 No No
4 empty 1.99 67.6 18.7 No No
5 empty 2.05 65.3 16.6 No No
6 empty 2.41 67.9 21.3 No No
7 empty 2.16 65.2 17 No No
8 empty 2.44 64.9 13.9 No No
9 empty 2.49 64.9 16.6 No No
10 empty 2.18 57 16.7 No No
3WAB_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 60.6 26.8 Yes No
2 empty 2.46 62.8 22.6 No No
3 bound 1.81 76 19.4 No No
4 empty 1.86 68.9 17.9 No No
5 empty 2.18 64 15.7 No No
6 empty 2.17 67.2 18.7 No No
7 empty 2.39 63.4 16.2 No No
8 empty 2.55 63.7 12.3 No No
9 empty 2.4 69.9 13.7 No No
10 empty 2.1 64.8 12.5 No No
3WC7_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 75.8 18.5 Yes No
2 empty 2.36 60.8 28.6 No No
3 empty 2.42 63.9 24 No No
4 empty 1.88 67.3 15.5 No No
5 empty 2.19 64.7 15.5 No No
6 empty 2.38 68.2 21.8 No No
7 empty 2.19 69.3 15.3 No No
8 empty 2.44 65.5 15.5 No No
9 empty 2.37 63.8 9 No No
10 empty 1.66 62.5 10.7 No No
1ZG9_B Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 77.9 15.7 Yes No
2 empty 1.85 70.3 22.8 No No
3 empty 2.4 61.4 16.2 No No
4 empty 2.11 66.3 16.7 No No
5 empty 1.98 67.4 14.4 No No
6 empty 2.33 67.3 15.4 No No
7 empty 2.08 62.1 16 No No
8 empty 2.47 70.2 8.3 No No
9 empty 1.81 66.8 11 No No
10 empty 2 64 10.8 No No
2PIZ_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 76.7 18.4 Yes No
2 empty 2.08 66.6 21 No No
3 empty 2.21 62.1 21.3 No No
4 empty 2.32 64.1 21.5 No No
5 empty 2.11 66.2 19.5 No No
6 empty 1.97 66.2 17.2 No No
7 empty 2.34 57.5 15.6 No No
8 empty 2.5 68.5 11.8 No No
9 empty 2.04 59.3 13.6 No No
10 empty 2.53 72.2 9 No No
1ZG7_A Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 78.7 19.5 Yes Yes
2 empty 2.03 69.1 19.9 No No
3 empty 2.46 71.6 20 No No
4 empty 2.24 68.2 12.5 No No
5 empty 2.03 68.3 14.4 No No
6 empty 2.25 67.2 20.2 No No
7 empty 2.42 65.6 10.7 No No
8 empty 2.48 68.3 12.3 No No
9 empty 2.17 57.8 15.5 No No
10 empty 1.75 57 13 No No
1ZG9_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 78.1 18.6 Yes No
2 empty 2.01 70.6 21.6 No No
3 empty 2.31 68.5 22.8 No No
4 empty 2.04 67.4 16.5 No No
5 empty 1.97 59.6 19.8 No No
6 empty 2.23 63.6 20.9 No No
7 empty 2.02 69.9 14.9 No No
8 empty 1.76 56.1 13.2 No No
9 empty 2.31 64 15.7 No No
10 empty 2.37 60.3 10 No No
2PJ7_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 62.2 30.1 Yes No
2 bound 1.91 78.2 18.9 No No
3 empty 1.86 72.7 15.1 No No
4 empty 2.16 68.3 16.2 No No
5 empty 2.43 71.6 16.5 No No
6 empty 2.36 58.7 14.9 No No
7 empty 2 66.7 19.2 No No
8 empty 2.04 58.4 15.7 No No
9 empty 1.87 65.7 10.7 No No
10 empty 2.16 61.9 9.3 No No
2JEW_A Carboxypeptidase B No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 67.3 20.3 No No
2 empty 1.85 66.3 18.3 No No
3 empty 2.47 63.2 15.2 No No
4 empty 2.31 67.6 13.5 No No
5 empty 2.07 67.3 11.5 No No
6 empty 1.91 59.4 20 No No
7 empty 1.88 55.5 18.1 No No
8 empty 2.38 70.2 9.6 No No
9 empty 2 73.3 17.7 No No
10 empty 2.22 61.6 13.7 No No
1PBA_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 59.7 24.2 Yes No
2 empty 2.14 61.2 10.1 No No
3 empty 2.59 60.8 10.2 No No
4 empty 2.13 63.7 7.7 No No
5 empty 1.66 68.6 9.9 No No
6 empty 2.18 76.3 9.2 No No
7 empty 2.51 57.5 11.3 No No
8 empty 2.69 52.1 8 No No
9 empty 1.37 100 0 Yes No
10 empty 2.61 69 6.1 No No
2PJ0_A Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 80.7 17.9 Yes Yes
2 empty 2.31 64 27.8 No No
3 empty 1.92 72.6 15.5 No No
4 empty 2.36 63.7 16.5 No No
5 empty 2.1 69.3 17 No No
6 empty 2.08 64.3 20.8 No No
7 empty 2.36 56.7 13.9 No No
8 empty 1.73 57.9 11.5 No No
9 empty 2.41 67.2 12.5 No No
10 empty 1.97 59.6 14 No No
4UIB_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 73.9 18.7 Yes No
2 empty 2.3 62.3 19.7 No No
3 bound 2.52 63.9 16 No No
4 empty 1.89 67.4 16.6 No No
5 bound 2.27 70.7 9 No No
6 empty 2.03 67.7 20.4 No No
7 empty 1.88 57.6 16.4 No No
8 empty 2.37 63 11.7 No No
9 empty 2.48 65.7 16.1 No No
10 empty 2.11 58.9 13.2 No No
5JC6_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 75.7 20 Yes No
2 empty 2.44 63.4 24 No No
3 empty 1.91 68.3 15.7 No No
4 empty 2.19 64.1 18.1 No No
5 empty 2.05 65.4 17.7 No No
6 empty 2.21 61.1 16.8 No No
7 empty 2.36 62.8 18.8 No No
8 empty 2.13 68.7 18.1 No No
9 empty 2.48 65.5 11.5 No No
10 empty 1.65 59.6 13.1 No No
2PJ5_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 68.8 34.1 Yes No
2 bound 1.87 78.5 20.8 No No
3 empty 1.88 73.9 15.5 No No
4 empty 2.13 67.9 14 No No
5 empty 2.05 65.7 19.2 No No
6 empty 2.45 71.9 11.6 No No
7 empty 1.99 59.7 16.1 No No
8 empty 2.06 59.4 9.5 No No
9 empty 2.47 60 10.4 No No
10 empty 2.06 56.9 10.6 No No
1ZG9_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 77.8 16.9 Yes No
2 empty 1.98 66 20.8 No No
3 empty 2.28 65.1 27 No No
4 empty 2.32 64.4 17.4 No No
5 empty 2.09 66.5 19.6 No No
6 empty 2.1 58 15.6 No No
7 empty 1.74 58.5 13.6 No No
8 empty 1.91 69.3 13.1 No No
9 empty 2.17 62.7 11.6 No No
10 empty 2.47 67 9 No No
2PJC_A Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 79.8 18.7 Yes Yes
2 empty 2.32 64.2 33.7 No No
3 empty 1.9 72.9 14.2 No No
4 empty 2.05 68.7 16.6 No No
5 empty 2.54 71.4 16 No No
6 empty 1.93 68.1 19.1 No No
7 empty 2.46 58 15 No No
8 empty 2.08 63 13.6 No No
9 empty 2.19 60.2 9.2 No No
10 empty 2.01 60.6 10.4 No No
2PJ5_B Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 78.4 16.6 Yes No
2 empty 2 68.2 22 No No
3 empty 2.5 62.9 16.4 No No
4 empty 2.41 60.7 16 No No
5 empty 2.26 58.6 18.2 No No
6 empty 1.9 70.1 16.4 No No
7 empty 2.16 66.5 14.4 No No
8 empty 1.82 59 13.7 No No
9 empty 2.42 67.8 10.6 No No
10 empty 2.09 55.4 14.9 No No
5LYL_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 78.4 18.7 Yes No
2 empty 2.49 66.2 15.8 No No
3 empty 1.92 64.4 16.5 No No
4 empty 2.51 63.6 22.4 No No
5 empty 2.28 72.2 13 No No
6 empty 2.03 70.1 12.6 No No
7 empty 2.43 68.8 16.9 No No
8 empty 2.27 63.3 12.2 No No
9 empty 2.54 61.2 15.8 No No
10 empty 1.93 58.4 14.3 No No
2PJ4_B Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 78.3 17 Yes No
2 empty 2.17 65.8 17.4 No No
3 empty 2.34 64.2 15.9 No No
4 empty 2.18 69.3 14 No No
5 empty 2.43 64.4 14.2 No No
6 empty 2.44 68.2 18.6 No No
7 empty 2.03 65.3 17.3 No No
8 empty 2.5 67.4 15.3 No No
9 empty 2.13 60.5 13.9 No No
10 empty 1.68 65.6 10.6 No No
5LRG_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 63.3 27.2 Yes No
2 empty 1.89 78.5 20 No No
3 empty 2.22 66.9 14.6 No No
4 empty 2.5 67.1 22.7 No No
5 empty 2.37 57.7 14.5 No No
6 empty 2.19 66.2 15.2 No No
7 empty 2 59.5 16.6 No No
8 empty 2.16 59.6 17.9 No No
9 empty 2.13 67.8 19.2 No No
10 empty 2.3 62.5 13.9 No No
1ZG8_B Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 78 17.1 Yes No
2 empty 1.91 68.3 24 No No
3 empty 2.49 59.6 18.9 No No
4 empty 2 67.6 13.7 No No
5 empty 2.11 66.1 13.2 No No
6 empty 2.43 69.9 8.4 No No
7 empty 2.25 59.9 12 No No
8 empty 2.28 67.6 11.7 No No
9 empty 2.36 57.4 12.7 No No
10 empty 2.66 58.1 16.2 No No
5LRK_B Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 79.9 19 Yes Yes
2 empty 2.11 68 23.1 No No
3 empty 2.54 63.4 16.4 No No
4 empty 2.38 64.9 15.9 No No
5 empty 2.1 65.6 12.1 No No
6 empty 2.21 63.5 17.6 No No
7 empty 2.01 68.2 18.6 No No
8 empty 2.12 52.4 16.5 No No
9 empty 2.03 56.3 11.7 No No
10 empty 2.33 61.1 10.8 No No
1ZG7_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 77.4 19.8 Yes No
2 empty 2.31 65.1 28.5 No No
3 empty 2.23 68.9 21.5 No No
4 empty 2.06 60.1 21.2 No No
5 empty 2.45 68.1 12.6 No No
6 empty 2.07 60.6 15.6 No No
7 empty 1.96 69.7 18.4 No No
8 empty 2.31 69.8 10.6 No No
9 empty 2.47 60.1 10.3 No No
10 empty 2.33 64 12.1 No No
2PJ8_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 78.1 18.8 Yes No
2 empty 2.17 66.3 22.4 No No
3 empty 2.32 66.8 19.3 No No
4 empty 2.23 58.1 14 No No
5 empty 2.18 58 14.1 No No
6 empty 2.61 71.4 18.6 No No
7 empty 2.24 69.9 14.7 No No
8 empty 1.94 70 17.3 No No
9 empty 2.07 60.4 10.9 No No
10 empty 2.43 69.8 12.1 No No
2PIY_B Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 75.6 18 Yes No
2 empty 1.96 69.2 21.7 No No
3 empty 2.38 63.5 17.5 No No
4 empty 2.57 65.6 21.4 No No
5 empty 1.92 60.2 19.7 No No
6 empty 2.38 69.5 15.8 No No
7 empty 2.12 69.9 14.2 No No
8 empty 2.36 54.9 16.7 No No
9 empty 1.92 68.6 14.4 No No
10 empty 1.81 56.3 14.4 No No
2PJ7_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 75.2 19.3 Yes No
2 empty 2.72 67.8 21.6 No No
3 empty 2.46 63.1 15.1 No No
4 empty 2.28 56.1 16.4 No No
5 empty 2.15 69.4 18.1 No No
6 empty 2.1 61.2 11.4 No No
7 empty 2.36 60.6 15.5 No No
8 empty 2.04 68.9 10.5 No No
9 empty 1.9 55.5 17 No No
10 empty 1.91 65.2 13.5 No No
1Z5R_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 78.6 17.4 Yes No
2 empty 2.23 69 24.2 No No
3 empty 2.52 70.1 23.4 No No
4 empty 2.2 62.6 14.5 No No
5 empty 2.47 69.5 17.3 No No
6 empty 2.09 58.9 11 No No
7 empty 2.36 71 11.9 No No
8 empty 1.9 68.6 16.8 No No
9 empty 2.02 61.3 12.8 No No
10 empty 2.19 67 7.9 No No
2PJ7_B Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 77.4 16.5 Yes No
2 empty 2.04 67.5 21.3 No No
3 empty 2.49 60.5 17 No No
4 empty 2.29 66.8 14.7 No No
5 empty 2.06 71.5 15.5 No No
6 empty 1.56 57.3 14.4 No No
7 empty 2.14 69.5 13 No No
8 empty 2.2 60.6 17 No No
9 empty 2.26 67.7 16.3 No No
10 empty 2.23 62.1 12.2 No No
2PIY_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 78 19.5 Yes No
2 empty 1.96 70.9 14.7 No No
3 empty 2.4 69.6 15.4 No No
4 empty 2.14 68.8 17.2 No No
5 empty 2.49 70.5 10.1 No No
6 empty 2.41 68.1 18 No No
7 empty 1.99 68.2 19.6 No No
8 empty 2.2 58.4 15.9 No No
9 empty 2.13 59.3 9.6 No No
10 empty 2.22 60.6 10.4 No No
1NSA_A Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 62.9 28.1 Yes No
2 bound 1.44 97.1 0 Yes Yes
3 empty 1.72 68.6 16.2 No No
4 empty 2.22 61.3 19.6 No No
5 empty 1.95 61.9 12.4 No No
6 empty 1.86 54.2 15.4 No No
7 empty 1.94 57.7 13.8 No No
8 empty 1.92 65.4 12.7 No No
9 empty 1.71 61.4 15.2 No No
10 empty 1.85 65.3 11.5 No No
2PJ2_C Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.65 79 17.3 Yes Yes
2 empty 2.1 66 22.1 No No
3 empty 2.55 70.3 21.6 No No
4 empty 2.52 68 13.1 No No
5 empty 2.34 69 17.3 No No
6 empty 2.09 70.9 17.6 No No
7 empty 2.25 59.3 16.4 No No
8 empty 2.15 61 12 No No
9 empty 2.39 58 13 No No
10 empty 2.4 67.4 9.4 No No
2PJA_B Carboxypeptidase B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 79.6 15.1 Yes Yes
2 empty 1.94 68.1 21.3 No No
3 empty 2.45 64.2 16.7 No No
4 empty 2.45 65.2 18.5 No No
5 empty 2.08 68.1 21.1 No No
6 empty 2.44 58.2 20.4 No No
7 empty 1.85 57.7 15.9 No No
8 empty 2.21 67 14.3 No No
9 empty 2.19 57.1 11.3 No No
10 empty 2.39 70 10.6 No No
5J1Q_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.52 62.8 34 Yes No
2 bound 1.83 77 18.2 No No
3 empty 2.37 70.1 21.5 No No
4 empty 1.86 68.6 16 No No
5 empty 2.18 64.9 16.2 No No
6 empty 2.39 68.6 15.1 No No
7 empty 1.93 70.2 13.9 No No
8 empty 2.61 54.6 16.5 No No
9 empty 2.42 62.6 10.2 No No
10 empty 2.47 65.5 15.1 No No
2PIZ_B Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 78.2 16.3 Yes No
2 empty 2.01 67 20.3 No No
3 empty 2.51 67.4 16.7 No No
4 empty 2.63 64.3 16.4 No No
5 empty 2.08 70 16.4 No No
6 empty 2.07 65.8 14.3 No No
7 empty 2.04 58.1 14.1 No No
8 empty 2.54 70.2 12.9 No No
9 empty 2.04 60.1 11.4 No No
10 empty 1.72 56.5 11.3 No No
2PJ1_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 76.2 18.5 Yes No
2 empty 2.17 65.3 21.6 No No
3 empty 2.52 67.9 19.2 No No
4 empty 2.4 69.5 9 No No
5 empty 2.21 57.9 14.9 No No
6 empty 2.08 59.7 12 No No
7 empty 2.15 69.5 20 No No
8 empty 2.31 61.5 15.3 No No
9 empty 2.03 60.4 12.3 No No
10 empty 1.98 61 12.4 No No
5LYF_A Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 75.9 16.2 Yes No
2 empty 2.48 67.8 24.8 No No
3 empty 2.38 60.5 21.6 No No
4 empty 1.94 67.5 18.2 No No
5 empty 2.33 70 9.7 No No
6 empty 1.86 68.5 16.8 No No
7 empty 2.22 61.9 14.1 No No
8 empty 2.14 66.5 11.4 No No
9 empty 2 58.2 15.8 No No
10 empty 2.14 56 14.4 No No
5LRK_C Carboxypeptidase B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 77.6 21.1 Yes No
2 empty 2.32 63.6 27.1 No No
3 empty 2.16 69.2 15.6 No No
4 empty 2.47 61.5 16.5 No No
5 empty 2.35 57.8 15.8 No No
6 empty 2.18 67.6 12.2 No No
7 empty 2.08 60.5 16.8 No No
8 empty 2 66.8 18.6 No No
9 empty 2.08 56.7 16.3 No No
10 empty 2.17 62.7 11.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed58
Domains assessed as druggable using the strict criteria22
Domains assessed as druggable using the relaxed criteria56

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1NSA_A (39066) Carboxypeptidase B Ferredoxin-like, Protease propeptides/inhibitors, Pancreatic carboxypeptidase activation domain 2.3Å Yes Yes
1NSA_A (33825) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 2.3Å Yes Yes
1PBA_A (39067) Carboxypeptidase B Ferredoxin-like, Protease propeptides/inhibitors, Pancreatic carboxypeptidase activation domain Yes No
1Z5R_B (124489) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.4Å Yes Yes
1Z5R_A (124488) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.4Å Yes Yes
1Z5R_C (124490) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.4Å Yes No
1ZG7_C (125016) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.75Å Yes No
1ZG7_A (125014) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.75Å Yes Yes
1ZG7_B (125015) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.75Å Yes Yes
1ZG8_A (125017) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 2Å Yes Yes
1ZG8_B (125018) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 2Å Yes No
1ZG8_C (125019) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 2Å No No
1ZG9_A (125020) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 2Å Yes No
1ZG9_B (125021) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 2Å Yes No
1ZG9_C (125022) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 2Å Yes No
2JEW_A (148025) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.4Å No No
2PIY_C (149524) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.43Å Yes No
2PIY_A (149522) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.43Å Yes No
2PIY_B (149523) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.43Å Yes No
2PIZ_B (149526) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.6Å Yes No
2PIZ_A (149525) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.6Å Yes Yes
2PIZ_C (149527) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.6Å Yes No
2PJ0_A (149528) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.64Å Yes Yes
2PJ0_B (149529) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.64Å Yes Yes
2PJ0_C (149530) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.64Å Yes No
2PJ1_A (149531) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.64Å Yes No
2PJ1_B (149532) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.64Å Yes No
2PJ1_C (149533) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.64Å Yes No
2PJ2_A (149534) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.95Å Yes No
2PJ2_C (149536) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.95Å Yes Yes
2PJ2_B (149535) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.95Å Yes Yes
2PJ3_A (149537) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.64Å Yes Yes
2PJ3_B (149538) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.64Å Yes Yes
2PJ3_C (149539) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.64Å Yes Yes
2PJ4_A (149540) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 2Å Yes No
2PJ4_B (149541) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 2Å Yes No
2PJ5_A (149542) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.65Å Yes No
2PJ5_C (149544) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.65Å Yes No
2PJ5_B (149543) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.65Å Yes No
2PJ6_A (149545) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.6Å Yes Yes
2PJ7_B (149547) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.77Å Yes No
2PJ7_A (149546) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.77Å Yes No
2PJ7_C (149548) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.77Å Yes No
2PJ8_A (149549) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.7Å Yes No
2PJ8_B (149550) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.7Å Yes No
2PJ8_C (149551) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.7Å Yes No
2PJ9_A (149552) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.44Å Yes No
2PJA_A (149553) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.7Å Yes Yes
2PJA_B (149554) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.7Å Yes Yes
2PJA_C (149555) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.7Å Yes No
2PJB_A (149556) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.7Å Yes No
2PJB_B (149557) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.7Å Yes Yes
2PJB_C (149558) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.7Å Yes No
2PJC_A (149559) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.74Å Yes Yes
2PJC_B (149560) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.74Å Yes No
2PJC_C (149561) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.74Å Yes No
3GLJ_A (3430807) Carboxypeptidase B Ferredoxin-like, Protease propeptides/inhibitors, Pancreatic carboxypeptidase activation domain 1.88Å Yes Yes
3GLJ_A (3430808) Carboxypeptidase B Phosphorylase/hydrolase-like, Zn-dependent exopeptidases, Pancreatic carboxypeptidases 1.88Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score