Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ALOX5 (P09917) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed8
Chains with at least one site assessed as druggable using the strict criteria8
Chains with at least one site assessed as druggable using the relaxed criteria8


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3V92_A Arachidonate 5-lipoxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 72.3 53.2 Yes Yes
2 empty 1.84 82.4 24 Yes Yes
3 empty 2.34 66.7 26.8 No No
4 empty 2.56 67.9 26.4 No No
5 empty 2.14 65.1 27.7 No No
6 empty 2.27 67 23.5 No No
7 empty 1.94 82.2 13.8 No No
8 empty 1.95 59.4 15.2 No No
9 empty 2.19 69.3 14.6 No No
10 empty 2.19 71.7 14.6 No No
3V99_A Arachidonate 5-lipoxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 73.2 44.4 Yes Yes
2 empty 2.27 65.5 39.3 No No
3 empty 1.84 72.8 22.3 No No
4 empty 2.26 61.7 19.7 No No
5 empty 1.95 58.7 23.7 No No
6 empty 2.21 60.1 18.1 No No
7 empty 1.97 69 12.3 No No
8 empty 2.05 63.6 13.9 No No
9 empty 1.59 57.7 15 No No
10 empty 2.23 77.7 9.7 No No
3V98_B Arachidonate 5-lipoxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 72.6 50 Yes Yes
2 empty 1.73 78.2 22.8 Yes No
3 empty 2.22 64.5 19.7 No No
4 empty 2.16 77.4 20.8 No No
5 empty 2.05 59.7 16.8 No No
6 empty 2.23 68.1 25.1 No No
7 empty 2.31 63.6 20.5 No No
8 empty 2.14 68.6 16 No No
9 empty 1.91 65.7 14.2 No No
10 empty 2.65 62.7 20.7 No No
3V92_B Arachidonate 5-lipoxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 75.3 57.2 Yes Yes
2 empty 1.8 76 36 No No
3 empty 2.28 67.4 33.7 No No
4 empty 2.07 72.6 28.8 No No
5 empty 2.13 63.9 19.9 No No
6 empty 2.32 68.8 14.3 No No
7 empty 1.99 73.1 14.6 No No
8 empty 2.08 67 22.2 No No
9 empty 1.87 65.9 14.2 No No
10 empty 1.82 59.4 13.8 No No
3O8Y_A Arachidonate 5-lipoxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 72.3 51.5 Yes Yes
2 empty 1.77 78.1 25.7 No No
3 empty 2.06 65.3 29.8 No No
4 empty 2.09 68.8 37.5 No No
5 empty 2.34 62.7 30.4 No No
6 empty 2.49 64.2 22.1 No No
7 empty 2.03 61.4 15 No No
8 empty 2.22 68.5 23.3 No No
9 empty 2.19 66.1 19.4 No No
10 empty 2 72.9 15.2 No No
3V99_B Arachidonate 5-lipoxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 71.4 87.7 Yes Yes
2 empty 1.74 81.1 24.1 Yes Yes
3 empty 1.95 69.2 21.3 No No
4 empty 1.88 67.3 32.8 No No
5 empty 2.33 67.1 23.9 No No
6 empty 2.15 67 17.6 No No
7 empty 2.01 72.8 12.3 No No
8 empty 2.02 67.4 17.4 No No
9 empty 2.15 68.6 11.7 No No
10 empty 1.76 57 12.7 No No
3V98_A Arachidonate 5-lipoxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 74.8 58.3 Yes Yes
2 empty 1.85 77.4 38.3 No No
3 empty 2.06 77.2 27.2 No No
4 empty 2.14 66.8 19.3 No No
5 empty 2.39 64.7 31.3 No No
6 empty 2.3 70.1 20.5 No No
7 empty 2.31 70.8 16.4 No No
8 empty 2.18 69.2 28.6 No No
9 empty 1.92 73.4 13.6 No No
10 empty 2.08 62.5 21.6 No No
3O8Y_B Arachidonate 5-lipoxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 73.9 54.1 Yes Yes
2 empty 1.71 76.8 23.3 Yes No
3 empty 2.22 63.8 29.4 No No
4 empty 2.04 72.7 29.7 No No
5 empty 2.45 69.7 29.5 No No
6 empty 2.3 64.6 22 No No
7 empty 1.95 72.7 12.3 No No
8 empty 2.18 68.4 15.7 No No
9 empty 2.1 59.2 14.5 No No
10 empty 1.02 98.3 0 Yes No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3O8Y_A (3650027) Arachidonate 5-lipoxygenase Lipoxigenase, Lipoxigenase, Animal lipoxigenases 2.389Å Yes No
3O8Y_A (3650026) Arachidonate 5-lipoxygenase Lipase/lipooxygenase domain (PLAT/LH2 domain), Lipase/lipooxygenase domain (PLAT/LH2 domain), UNMATCHED 2.389Å Yes No
Ligand-based Druggability Score: 1.35
Ligand-based Druggability Score Percentile: 93%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


ALOX5 is involved in 28 interactions in the network.


Druggability
Overall Druggability Percentile: 98.76
Druggability for Cancer Therapeutics: 81.62
Druggability for Other Therapeutics: 99.36
Cancer-Associated
Cancer-associated percentile : 83.63
Network Articulation Point
Is ALOX5 critical for communication in the network?


Detailed Graph Legend:Help