Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ALOX5 (P09917) - Overview - Molecular Target Synopsis

Protein


ALOX5, Arachidonate 5-lipoxygenase
Enzyme Classification 1.13.11.34
UniProt P09917

Also Known as LOX5_HUMAN, ALOX5, LOG5

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity.

3V92
S663A STABLE-5-LOX
RCSB/PDB
Inspect Structure
See all 3D Structures for ALOX5

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
674ENSG00000012779ENST00000374391ENSP00000363512P09917-1
642P09917-3
617ENSG00000012779ENST00000542434ENSP00000437634P09917-2
533P09917-4
484P09917-5

Drugs


ALOX5 is targeted by Approved Drugs Sulfasalazine, Zileuton. (see details)
Sulfasalazine
Zileuton

Sub-cellular localization


UniProt: ALOX5 is active in the following subcellular-locations: cytoplasm, nucleus matrix, nucleus membrane.
GO terms: ALOX5 is active in the following subcellular-locations: cytosol, extracellular region, extracellular space, ficolin-1-rich granule lumen, nuclear envelope, nuclear envelope lumen, nuclear matrix, nuclear membrane, nucleoplasm, secretory granule lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ALOX5 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HT29, HL_60, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KARPAS-422, TK, DOHH-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD20-positive B cell, CD14-positive monocyte, SK-N-SH

(see details)

3D Structures


For ALOX5 there are:
4 structures (8 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ALOX5 has been screened with 2716 compounds (5411 bioactivities), 881 compounds have bioactivities that show binding affinity of <= 500nM (1232 bioactivities). (see details)