Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
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putA (P09546) - Overview - Molecular Target Synopsis

Protein


putA, Bifunctional protein PutA
Enzyme Classification 1.5.5.2
UniProt P09546

Also Known as PUTA_ECOLI, putA, poaA

Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon. Homodimer.

4O8A
FIRST STRUCTURE OF A PROLINE UTILIZATION A PROLINE DEHYDROGENASE DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for putA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1320P09546-1

Sub-cellular localization


GO terms: putA is active in the following subcellular-locations: cytoplasmic side of plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project putA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For putA there are:
16 structures (26 chains) solved
13 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis