Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTM1 (P09488) - Overview - Molecular Target Synopsis

Protein


GSTM1, Glutathione S-transferase Mu 1
Enzyme Classification 2.5.1.18
UniProt P09488

Also Known as GSTM1_HUMAN, GSTM1, GST1

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Homodimer.

2F3M
STRUCTURE OF HUMAN GLUTATHIONE S-TRANSFERASE M1A-1A COMPLEXED WITH 1- (S-(GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXADIENATE ANION
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTM1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GSTM1 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTM1 is active in the following subcellular-locations: cytoplasm, cytosol, intercellular bridge.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTM1 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H460, U251, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, SW 780, MDA-MB-415

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For GSTM1 there are:
5 structures (20 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTM1 has been screened with 45 compounds (57 bioactivities). (see details)