Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

PAEP (P09466) - Overview - Molecular Target Synopsis


PAEP, Glycodelin
UniProt P09466

Also Known as PAEP_HUMAN, PAEP

Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155). Homodimer (PubMed:25422905, PubMed:9239694).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: PAEP is active in the following subcellular-locations: secreted.
GO terms: PAEP is active in the following subcellular-locations: extracellular region.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project PAEP has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_2, UACC_257, SF_539

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MeWo, 501A, IGR-37

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

3D Structures

For PAEP there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

PAEP has been screened with compounds ( bioactivities). (see details)