Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RBP1 (P09455) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed16
Chains with at least one site assessed as druggable using the strict criteria16
Chains with at least one site assessed as druggable using the relaxed criteria16


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6E5T_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 99.8 0 Yes Yes
2 empty 2.04 62.9 19.5 No No
3 empty 2.04 65.9 16 No No
4 empty 2.22 60.9 18.4 No No
5 empty 2.42 67.1 12.2 No No
6 empty 2.2 66.5 12.4 No No
7 empty 2 67.4 11.5 No No
8 empty 2.64 65.2 9.4 No No
9 empty 2.79 63.3 10.4 No No
10 empty 2.34 70.2 7.3 No No
6E6M_B Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.46 78.9 28.1 Yes Yes
2 empty 2.39 58.3 25.5 No No
3 empty 2.06 67.7 12.2 No No
4 empty 1.96 63.2 12.6 No No
5 empty 2.34 59.3 11.7 No No
6 empty 2.13 63.6 10.1 No No
7 empty 2.34 61.6 10.6 No No
8 empty 2.89 65.3 7.9 No No
9 empty 2.01 61.5 6.2 No No
10 empty 2.82 72.8 5.1 No No
5H8T_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 99.5 0 Yes Yes
2 empty 2.18 66.1 23.8 No No
3 empty 2.19 68.2 11.9 No No
4 empty 2.42 68.4 12.4 No No
5 empty 1.98 67.4 11.9 No No
6 empty 2.22 65.3 12.5 No No
7 empty 2.29 70.7 9.4 No No
8 empty 2.44 58.8 9.6 No No
9 empty 2.72 66.1 9.4 No No
10 empty 2.2 61.2 7.6 No No
5LJB_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.36 99.5 0 Yes Yes
2 empty 2.24 65.6 24.1 No No
3 empty 1.96 66.4 11.6 No No
4 empty 2.2 69.9 12.5 No No
5 empty 2.03 67.4 14.5 No No
6 empty 2.4 61.6 11.3 No No
7 empty 2.37 61.4 11.2 No No
8 empty 1.93 73.3 7 No No
9 empty 2.7 68.2 6.8 No No
10 empty 2.56 62.6 7.6 No No
5LJH_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.28 100 0 Yes Yes
2 empty 2.18 62.7 17.6 No No
3 empty 2 67.7 9.2 No No
4 empty 2.4 64.4 15 No No
5 empty 2.1 71 14 No No
6 empty 2.68 75.3 7.6 No No
7 empty 2.22 62.5 10 No No
8 empty 2.47 66.5 10.1 No No
9 empty 2.76 70.9 8.5 No No
10 empty 2.18 73.5 9.6 No No
5LJG_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.34 99 0 Yes Yes
2 empty 2.44 66 24.7 No No
3 empty 2.13 65.8 10.1 No No
4 empty 2.19 69.3 13 No No
5 empty 2.43 70 9.9 No No
6 empty 2.47 57.7 11.6 No No
7 empty 2.29 66.4 8.4 No No
8 empty 2.73 56.5 6.7 No No
9 empty 2.86 66.7 7.7 No No
10 empty 2.23 70.8 9.9 No No
5HBS_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 68.3 20.8 No No
2 bound 1.46 98.9 0 Yes Yes
3 empty 2.12 63 16.7 No No
4 empty 1.9 69.1 12.3 No No
5 empty 2.27 58.4 16.3 No No
6 empty 2.21 57.3 13.6 No No
7 empty 2.18 65.7 12.1 No No
8 empty 2.27 69.2 14.8 No No
9 empty 2.56 62.1 7.9 No No
10 empty 2.01 60.4 10 No No
5H9A_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.32 99.4 0 Yes Yes
2 empty 2 58.9 16.4 No No
3 empty 2.03 71.6 16.5 No No
4 empty 2.21 58.2 11.7 No No
5 empty 2.25 56.7 11.6 No No
6 empty 2.4 72.8 8.1 No No
7 empty 2 68.4 11 No No
8 empty 2.13 64.4 8.4 No No
9 empty 2.08 61.4 8.1 No No
10 empty 2.85 65.3 6.6 No No
5LJE_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.24 99.2 0 Yes Yes
2 empty 2.11 59.8 17.5 No No
3 empty 1.87 66.1 14.7 No No
4 empty 2.42 67.9 13.9 No No
5 empty 2.48 69.7 9.8 No No
6 empty 1.89 66 13.9 No No
7 empty 2.32 60.6 10.6 No No
8 empty 2.64 67.3 12.4 No No
9 empty 1.73 64 6.9 No No
10 empty 2.31 66.1 8.5 No No
5LJC_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.3 99.7 0 Yes Yes
2 empty 2.35 63.2 21.8 No No
3 empty 1.97 67.6 12.1 No No
4 empty 2.12 68 12.3 No No
5 empty 2.47 71.4 9.9 No No
6 empty 2.18 59.6 11.3 No No
7 empty 2.52 69 10 No No
8 empty 2.85 65.7 8.8 No No
9 empty 2.48 68.2 8.4 No No
10 empty 2.65 71.4 7.6 No No
6E6M_C Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.31 99.7 0 Yes Yes
2 empty 2.27 62.9 21.4 No No
3 empty 2.23 65.2 17.6 No No
4 empty 2.28 61.6 13.3 No No
5 empty 2.03 70.6 11.9 No No
6 empty 2.16 64.3 14.5 No No
7 empty 2.17 62.6 10.4 No No
8 empty 2.87 66.1 8.2 No No
9 empty 2.41 69.7 7 No No
10 empty 2.51 59.4 7.5 No No
6E6M_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.36 81.7 25.3 Yes Yes
2 empty 2.22 56.2 20.3 No No
3 empty 2.03 60.7 19.4 No No
4 empty 2.33 62.9 10.2 No No
5 empty 2.1 62.6 14.2 No No
6 empty 2.03 71.4 7.4 No No
7 empty 2.52 61.8 15.2 No No
8 empty 2.29 65.5 7.8 No No
9 empty 2.77 64.9 10.1 No No
10 empty 2.57 63.3 6.3 No No
5HA1_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 66.8 33.8 Yes Yes
2 bound 1.43 99.8 0 Yes Yes
3 empty 2.35 58.7 17 No No
4 empty 2.25 63.1 11.3 No No
5 empty 2.01 69.5 7.4 No No
6 empty 2.21 58.4 9.3 No No
7 empty 2.52 62.7 10.5 No No
8 empty 2.59 74.6 7.9 No No
9 empty 1.86 69.8 8.9 No No
10 empty 2.49 63.2 7.9 No No
5LJD_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.24 99.3 0 Yes Yes
2 empty 2.19 62 16.8 No No
3 empty 2.01 66.6 11.7 No No
4 empty 2.28 62.6 16.4 No No
5 empty 2.26 70.2 12.4 No No
6 empty 2.49 67.1 11.7 No No
7 empty 2.54 69.3 8.4 No No
8 empty 2.43 60.2 11.7 No No
9 empty 2.31 66.5 8.8 No No
10 empty 2.14 69.8 10.3 No No
6E5L_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.34 99.7 0 Yes Yes
2 empty 2.13 63.8 23.9 No No
3 empty 2.01 68.3 11.4 No No
4 empty 2.28 56.9 20 No No
5 empty 2.4 67 11.5 No No
6 empty 2.31 58.2 15.3 No No
7 empty 1.95 68.1 9.7 No No
8 empty 2.71 70.5 9.3 No No
9 empty 2.79 63.8 11.7 No No
10 empty 2.51 65.6 7.8 No No
5LJK_A Retinol-binding protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.33 99.8 0 Yes Yes
2 empty 2 67.6 16.6 No No
3 empty 2.47 67.8 9 No No
4 empty 2.31 68.2 11 No No
5 empty 2.47 69.5 8.6 No No
6 empty 2.27 59.4 11.5 No No
7 empty 2.31 67.2 9.1 No No
8 empty 2.36 66.9 9.1 No No
9 empty 2.64 64.4 10.8 No No
10 empty 2.9 69.2 6.3 No No
Ligand-based Druggability Score: 0.35
Ligand-based Druggability Score Percentile: 83%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RBP1 is involved in 14 interactions in the network.


Druggability
Overall Druggability Percentile: 45.71
Druggability for Cancer Therapeutics: 81.44
Druggability for Other Therapeutics: 27.26
Cancer-Associated
Cancer-associated percentile : 84.71
Network Articulation Point
Is RBP1 critical for communication in the network?


Detailed Graph Legend:Help