Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RBP1 (P09455) - Overview - Molecular Target Synopsis

Protein


RBP1, Retinol-binding protein 1
UniProt P09455

Also Known as RET1_HUMAN, RBP1, CRBP1

Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665496). Interacts (only as retinol-free apoprotein) with STRA6.

6E6M
CRYSTAL STRUCTURE OF HUMAN CELLULAR RETINOL-BINDING PROTEIN 1 IN COMPLEX WITH CANNABIDIORCIN (CBDO)
RCSB/PDB
Inspect Structure
See all 3D Structures for RBP1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RBP1 is active in the following subcellular-locations: cytoplasm, lipid droplet.
GO terms: RBP1 is active in the following subcellular-locations: cytosol, lipid droplet, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RBP1 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SW_620, OVCAR_5, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SW 480, NCI-H520, SW 527

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: IMR-90, SK-N-SH_RA, AG445

(see details)

RNA Interference


RBP1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For RBP1 there are:
14 structures (16 chains) solved
12 are solved in complex with at least one small molecule ligand
6 are solved with an approved drug

RBP1 is solved in complex with the approved drug(s):

RTL/RETINOL (5H8T_A, 5HBS_A, 5LJB_A, 5LJC_A, 5LJD_A, 5LJE_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RBP1 has been screened with compounds ( bioactivities). (see details)