Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTP1 (P09211) - Overview - Molecular Target Synopsis

Protein


GSTP1, Glutathione S-transferase P
Enzyme Classification 2.5.1.18
UniProt P09211

Also Known as GSTP1_HUMAN, GSTP1, FAEES3, GST3

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5.

6AP9
CRYSTAL STRUCTURE OF HGSTP1-1 WITH S-NITROSATION OF CYS101
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTP1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
210ENSG00000084207ENST00000398606ENSP00000381607P09211-1
174ENSG00000084207ENST00000398603ENSP00000381604

Sub-cellular localization


UniProt: GSTP1 is active in the following subcellular-locations: cytoplasm, mitochondrion, nucleus.
GO terms: GSTP1 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, mitochondrion, nucleus, plasma membrane, secretory granule lumen, TRAF2-GSTP1 complex, vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTP1 has gain in 13 cell-lines, loss in 0 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, OVCAR_4, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PLC/PRF/5, Okajima, MEL-HO

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HMEC, HUVEC

(see details)

3D Structures


For GSTP1 there are:
64 structures (143 chains) solved
61 are solved in complex with at least one small molecule ligand
11 are solved with an approved drug

GSTP1 is solved in complex with the approved drug(s):

EAA/ETHACRYNIC ACID (11GS_A, 11GS_B, 2GSS_A, 2GSS_B, 3DGQ_A, 3GSS_A, 3GSS_B, 3HJO_A, 3HJO_B, 3KM6_A, 3KM6_B, 3KMO_A, 3KMO_B, 3N9J_A, 3N9J_B),
GDS/OXIGLUTATIONE (6AP9_A, 6AP9_B),
CBL/CHLORAMBUCIL (3CSJ_B),
SAS/SULFASALAZINE (13GS_A, 13GS_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTP1 has been screened with 251 compounds (309 bioactivities), 17 compounds have bioactivities that show binding affinity of <= 500nM (17 bioactivities). (see details)