Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTA2 (P09210) - Overview - Molecular Target Synopsis

Protein


GSTA2, Glutathione S-transferase A2
Enzyme Classification 2.5.1.18
UniProt P09210

Also Known as GSTA2_HUMAN, GSTA2, GST2

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Homodimer or heterodimer of GSTA1 and GSTA2.

4ACS
CRYSTAL STRUCTURE OF MUTANT GST A2-2 WITH ENHANCED CATALYTIC EFFICIENCY WITH AZATHIOPRINE
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTA2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
222ENSG00000244067ENST00000493422ENSP00000420168P09210-1

Sub-cellular localization


UniProt: GSTA2 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTA2 is active in the following subcellular-locations: cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTA2 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, SN12C, U251

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: VMRC-LCD, huH-1, UMC-11

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For GSTA2 there are:
4 structures (22 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTA2 has been screened with 39 compounds (52 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)