Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

traD (P09130) - Overview - Molecular Target Synopsis

Protein


traD, Coupling protein TraD
UniProt P09130

Also Known as TRAD1_ECOLI, traD

Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Couples the transferosome to a type IV secretion system. Probably forms a pore through which single-stranded plasmid DNA is transferred to the secretion system. The last 37 residues are important for determining plasmid specificity and transfer efficiency, with additional specificity conferred by the TraD-TraM pair. Interacts with relaxosome component TraM. May form a hexamer in the membrane.

3D8A
7 RESIDUE FRAGMENT OF
PROTEIN TRAD
IN THE STRUCTURE OF
CO-CRYSTAL STRUCTURE OF TRAM-TRAD COMPLEX.
RCSB/PDB
Inspect Structure
See all 3D Structures for traD

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
717P09130-1

Sub-cellular localization


UniProt: traD is active in the following subcellular-locations: cell inner membrane.
GO terms: traD is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project traD has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For traD there are:
1 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis