Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ABHD2 (P08910) - Overview - Molecular Target Synopsis


ABHD2, Monoacylglycerol lipase ABHD2
Enzyme Classification
UniProt P08910

Also Known as ABHD2_HUMAN, ABHD2, LABH2

Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (PubMed:27247428). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: ABHD2 is active in the following subcellular-locations: cell membrane, cell projection, cilium, flagellum membrane.
GO terms: ABHD2 is active in the following subcellular-locations: acrosomal vesicle, integral component of membrane, sperm flagellum, sperm plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ABHD2 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: COLO205, M14, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCUM-1, COLO 205, DMS 454

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, MCF-7

(see details)