Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

ptsI (P08839) - Overview - Molecular Target Synopsis

Protein


ptsI, Phosphoenolpyruvate-protein phosphotransferase
Enzyme Classification 2.7.3.9
UniProt P08839

Also Known as PT1_ECOLI, ptsI

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (PubMed:7876255, PubMed:12705838, PubMed:17053069). Can also use (Z)-3-fluoro-PEP (ZFPEP), (Z)-3-methyl-PEP (ZMePEP), (Z)-3-chloro-PEP (ZClPEP) and (E)-3-chloro-PEP (EClPEP) as alternative phosphoryl donors (PubMed:12705838). Homodimer.

2N5T
ENSEMBLE SOLUTION STRUCTURE OF THE PHOSPHOENOLPYRUVATE-ENZYME I COMPLEX FROM THE BACTERIAL HOSPHOTRANSFERASE SYSTEM
RCSB/PDB
Inspect Structure
See all 3D Structures for ptsI

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
575P08839-1

Sub-cellular localization


UniProt: ptsI is active in the following subcellular-locations: cytoplasm.
GO terms: ptsI is active in the following subcellular-locations: cytosol, phosphoenolpyruvate-dependent sugar phosphotransferase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ptsI has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ptsI there are:
17 structures (23 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis