Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(P08659) - Overview - Molecular Target Synopsis

Protein


, Luciferin 4-monooxygenase
Enzyme Classification 1.13.12.7
UniProt P08659

Also Known as LUCI_PHOPY

Produces green light with a wavelength of 562 nm.

5WYS
LUCIFERASE WITH INHIBITOR 3I
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
550P08659-1

Sub-cellular localization


UniProt: is active in the following subcellular-locations: peroxisome.
GO terms: is active in the following subcellular-locations: peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For there are:
16 structures (20 chains) solved
11 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (5GYZ_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


has been screened with 511 compounds (671 bioactivities), 43 compounds have bioactivities that show binding affinity of <= 500nM (43 bioactivities). (see details)