Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
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Gene Copy Number Variation
RNAi
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HCK (P08631) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Protein tyrosine kinase (100%) (view alignment) Lyn (P25911) - MOUSE 2ZV8_A 83.21 0 2.7Å ANP 2008-11-11
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3DQX_B 69.49 2.0E-116 2.3Å AMP 2008-09-23
Protein tyrosine kinase (100%) (view alignment) FYN (P06241) - HUMAN 2DQ7_X 70.59 5.0E-118 2.8Å STU 2006-07-04
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5TEH_B 69.12 8.0E-116 2.99Å S56 2017-09-27
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3ACK_A 76.41 0 2.6Å KSR 2010-06-30
Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 2HK5_A 100 0 2Å 1BM 2006-09-05
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2HWO_A 69.12 7.0E-116 2.48Å RBS 2007-02-27
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 6ATE_A 69.49 1.0E-116 2.4Å 6H3 2019-02-27
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 4YBJ_A 69.49 2.0E-116 2.61Å 4A9 2016-03-02
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS0_A 100 0 2.93Å VS0 2013-05-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3F3V_B 69.12 7.0E-116 2.6Å 1BU 2009-06-02
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 2C0T_A 100 0 2.14Å L3G 2006-09-20
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3QLG_A 69.12 5.0E-116 2.75Å 1N1 2012-02-08
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 2C0I_B 100 0 2.3Å L1G 2006-09-20
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3TZ8_A 69.12 7.0E-116 2.7Å AQM 2012-10-10
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3G6H_A 69.12 1.0E-115 2.35Å - 2009-03-24
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4O2P_B 69.49 2.0E-116 2.1Å 11V 2015-03-04
SH3 domain (100%) (view alignment) HCK (P08631) - HUMAN 1BU1_B 100 0 2.6Å - 1998-11-11
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5K9I_A 69.49 2.0E-116 2.5Å O44 2017-02-01
SH3 domain (100%) (view alignment) HCK (P08631) nef (P03407) HUMAN 3REA_D 100 0 2Å - 2011-06-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3F3T_B 69.12 7.0E-116 2.5Å - 2009-03-03
Protein tyrosine kinase (100%) (view alignment) - 4CSV_A 60 2.0E-93 2.05Å STI 2015-03-04
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5J5S_B 69.49 2.0E-116 2.15Å 6G3 2016-06-01
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS6_B 100 0 2.37Å VSH 2013-05-01
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3BYU_A 76.45 2.0E-129 2.3Å AM6 2008-09-16
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS2_B 100 0 2.609Å VSB 2013-05-01
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 1OPL_B 39.85 6.0E-102 3.4Å P16 2003-04-08
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 1AD5_B 100 0 2.6Å ANP 1997-05-15
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3EN7_A 69.49 2.0E-116 2.8Å ABJ 2008-10-14
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3G5D_A 69.12 7.0E-116 2.2Å 1N1 2009-06-02
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VRY_B 100 0 2.48Å B43 2013-05-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3F3W_A 68.75 3.0E-115 2.6Å 1BU 2009-06-02
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3BYO_A 76.75 5.0E-127 2Å AM9 2008-12-30
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3TZ9_A 69.12 7.0E-116 3.1Å AQU 2012-10-10
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5D11_A 68.75 3.0E-115 2.3Å 56G 2015-09-09
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 4LUD_A 100 0 2.85Å SK8 2014-02-12
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 4U5J_B 69.49 2.0E-116 2.26Å RXT 2014-09-17
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3EN6_B 69.49 2.0E-116 2.39Å KS5 2008-10-14
SH3 domain (100%) (view alignment) HCK (P08631) - HUMAN 1BU1_A 100 0 2.6Å - 1998-11-11
SH3 domain (100%) (view alignment) HCK (P08631) - HUMAN 4HCK_A 100 0 - 1998-06-17
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 2OG8_B 76.98 2.0E-124 2.3Å 1N8 2007-02-27
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5SWH_A 69.12 8.0E-116 2.5Å 71D 2017-08-16
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2QLQ_A 69.12 7.0E-116 2.33Å SR2 2008-03-11
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 1YOM_A 69.49 4.0E-116 2.7Å P01 2006-01-27
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3G5D_B 69.12 7.0E-116 2.2Å 1N1 2009-06-02
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VRZ_A 100 0 2.218Å VRZ 2013-05-01
SH3 domain (100%) (view alignment) HCK (P08631) - HUMAN 1BU1_E 100 0 2.6Å - 1998-11-11
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 4MXZ_B 68.75 1.0E-115 2.58Å DB8 2013-12-04
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2QI8_A 68.75 3.0E-115 2.32Å - 2008-03-18
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5T0P_B 69.12 8.0E-116 2.5Å 73A 2017-08-23
SH3 domain (45%) (view alignment) HCK (P08631) (Q5QGG3) HUMAN 5NUH_C 100 0 2.78Å - 2017-08-16
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3EL8_B 69.49 2.0E-116 2.3Å - 2008-10-28
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3G6G_B 69.49 2.0E-116 2.3Å G6G 2009-03-24
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3SVV_B 69.12 1.0E-115 2.2Å VSP 2011-08-17
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 4MXY_A 68.75 1.0E-115 2.58Å DB8 2013-12-25
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4MCV_B 69.12 2.0E-115 2.73Å 29K 2013-11-20
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS4_A 100 0 2.747Å VSF 2013-05-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3DQW_B 69.12 1.0E-115 2.01Å AGS 2008-09-23
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3DQW_A 69.12 1.0E-115 2.01Å AGS 2008-09-23
Protein tyrosine kinase (100%) (view alignment) Lyn (P25911) - MOUSE 2ZVA_A 83.21 0 2.6Å 1N1 2008-11-11
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3EL7_A 69.49 2.0E-116 2.8Å PD3 2008-10-28
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3F6X_D 69.49 2.0E-116 2.35Å IHH 2008-12-09
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 1QCF_A 100 0 2Å PP1 1999-06-08
SH3 domain (100%) (view alignment) HCK (P08631) nef (P03407) HUMAN 3RBB_B 100 0 2.35Å - 2011-04-27
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 2H8H_A 63.12 0 2.2Å H8H 2006-11-21
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 1YOJ_B 69.49 4.0E-116 1.95Å - 2006-01-27
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 4C3F_A 76.89 6.0E-124 1.72Å 7KW 2013-10-23
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 2OF4_A 76.75 5.0E-127 2.7Å 979 2007-02-27
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5K9I_B 69.49 2.0E-116 2.5Å O44 2017-02-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4LGH_B 69.12 2.0E-115 2.84Å 0JN 2013-08-07
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 1YI6_A 69.37 7.0E-116 2Å - 2006-05-02
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 1QPE_A 76.7 1.0E-130 2Å PP2 2000-05-31
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS5_B 100 0 2.85Å VSG 2013-05-01
Protein tyrosine kinase (100%) (view alignment) LYN (P07948) - HUMAN 3A4O_X 82.5 0 3Å STU 2009-12-08
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VRZ_B 100 0 2.218Å VRZ 2013-05-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2QLQ_B 69.12 7.0E-116 2.33Å SR2 2008-03-11
SH3 domain (100%) (view alignment) HCK (P08631) nef (P03407) HUMAN 4ORZ_A 100 0 2Å - 2014-03-26
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2HWP_B 69.12 7.0E-116 2.47Å DJK 2007-02-27
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2QQ7_B 68.75 3.0E-115 2.38Å SR2 2008-03-11
SH3 domain (100%) (view alignment) HCK (P08631) - HUMAN 2OI3_A 100 0 - 2007-02-20
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3B2W_A 76.53 1.0E-129 2.3Å 9NH 2007-12-18
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3TZ8_B 69.12 7.0E-116 2.7Å AQM 2012-10-10
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2HWO_B 69.12 7.0E-116 2.48Å RBS 2007-02-27
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3UQG_A 69.49 2.0E-116 2.2Å B5A 2012-03-14
SH3 domain (100%) (view alignment) HCK (P08631) nef (P03407) HUMAN 3REA_B 100 0 2Å - 2011-06-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5J5S_A 69.49 2.0E-116 2.15Å 6G3 2016-06-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3EN5_A 69.49 2.0E-116 2.65Å KS4 2008-10-14
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 1AD5_A 100 0 2.6Å ANP 1997-05-15
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5SYS_B 69.12 8.0E-116 2.8Å 72F 2017-08-16
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3KXZ_A 76.41 0 2.37Å 925 2010-06-23
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VRY_A 100 0 2.48Å B43 2013-05-01
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) Csk (P32577) - NORWAY RAT 1K9A_F 37.89 1.0E-79 2.5Å - 2002-03-20
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) CSK (P41240) CHICKEN 3D7U_D 69.49 4.0E-116 4.012Å - 2008-08-05
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3MPM_A 76.89 6.0E-124 1.95Å 5LK 2010-06-02
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 4MXO_A 69.49 1.0E-116 2.1Å DB8 2013-12-04
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4FIC_B 69.49 2.0E-116 2.5Å 0UL 2013-04-10
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5XP7_A 69.49 2.0E-116 2Å 8C6 2017-09-06
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 1YOL_A 69.85 1.0E-116 2.3Å S03 2006-01-27
SH3 domain (100%) (view alignment) HCK (P08631) - HUMAN 1BU1_C 100 0 2.6Å - 1998-11-11
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3LCK_A 76.75 5.0E-127 1.7Å - 1997-12-03
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5TEH_A 69.12 8.0E-116 2.99Å S56 2017-09-27
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3LOK_A 68.75 3.0E-115 2.48Å DJK 2010-12-22
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 2HCK_B 100 0 3Å QUE 1997-08-20
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 2PL0_A 76.41 0 2.8Å STI 2007-10-09
SH3 domain (100%), SH2 domain (100%) (view alignment) HCK (P08631) nef (P03407) HUMAN 4U5W_B 100 0 1.86Å - 2014-08-20
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3UQF_B 69.49 2.0E-116 2.27Å BK5 2012-03-14
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 4MXZ_A 68.75 1.0E-115 2.58Å DB8 2013-12-04
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3QLF_A 69.12 5.0E-116 2.75Å PD5 2012-02-08
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3OF0_B 69.12 5.0E-116 2.7Å - 2011-08-17
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4O2P_A 69.49 2.0E-116 2.1Å 11V 2015-03-04
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) Csk (P32577) - NORWAY RAT 1K9A_E 37.89 1.0E-79 2.5Å - 2002-03-20
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 5MO4_A 43.69 1.0E-100 2.166Å NIL AY7 2017-04-05
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - 4AGW_A 69.49 2.0E-116 2.5Å MES NG7 2012-02-15
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3OEZ_A 69.12 5.0E-116 2.4Å STI 2011-08-17
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 1FMK_A 63.12 0 1.5Å - 1997-08-20
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - 4AGW_B 69.49 2.0E-116 2.5Å MES NG7 2012-02-15
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5SWH_B 69.12 8.0E-116 2.5Å 71D 2017-08-16
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3QLG_B 69.12 5.0E-116 2.75Å 1N1 2012-02-08
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 4MXY_B 68.75 1.0E-115 2.58Å DB8 2013-12-25
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2FO0_A 43.92 3.0E-101 2.27Å P16 2006-03-21
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5T0P_A 69.12 8.0E-116 2.5Å 73A 2017-08-23
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 4LUD_B 100 0 2.85Å SK8 2014-02-12
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3F6X_A 69.49 2.0E-116 2.35Å IHH 2008-12-09
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3F3V_A 69.12 7.0E-116 2.6Å 1BU 2009-06-02
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 5H0G_A 100 0 1.8Å OOU 2017-10-04
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 4YBK_A 69.49 2.0E-116 2.5Å 4B7 2016-03-02
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5BMM_A 69.49 2.0E-116 2.5Å - 2016-09-21
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3DQW_C 69.12 1.0E-115 2.01Å AGS 2008-09-23
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS7_A 100 0 2.95Å KS1 2013-05-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3U4W_A 69.26 6.0E-115 1.9Å 08L 2012-02-22
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 2SRC_A 63.12 0 1.5Å ANP 1999-07-22
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5D12_B 68.75 3.0E-115 3Å G97 2015-09-09
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3LOK_B 68.75 3.0E-115 2.48Å DJK 2010-12-22
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 2ZM1_A 76.41 0 2.1Å KSF 2008-10-14
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3QLF_B 69.12 5.0E-116 2.75Å PD5 2012-02-08
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3OF0_A 69.12 5.0E-116 2.7Å - 2011-08-17
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2OIQ_B 69.49 2.0E-116 2Å - 2007-03-20
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 2ZM4_A 76.41 0 2.7Å KSM 2008-10-14
SH3 domain (100%) (view alignment) HCK (P08631) - HUMAN 1BU1_F 100 0 2.6Å - 1998-11-11
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 2C0T_B 100 0 2.14Å L3G 2006-09-20
Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 5ZJ6_B 100 0 1.696Å VSE 2018-06-06
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 2BDF_A 69.49 1.0E-116 2.1Å 24A 2006-10-24
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 1QPJ_A 76.7 1.0E-130 2.2Å STU 2000-05-31
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3TZ7_B 69.12 7.0E-116 3.3Å AQB 2012-10-10
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 2HCK_A 100 0 3Å QUE 1997-08-20
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2QQ7_A 68.75 3.0E-115 2.38Å SR2 2008-03-11
SH3 domain (100%) (view alignment) HCK (P08631) - HUMAN 2OJ2_A 100 0 - 2007-01-30
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3KMM_A 76.51 0 2.8Å LHL 2010-12-08
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3AD5_A 76.41 0 2Å 5PB 2011-01-19
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3F6X_B 69.49 2.0E-116 2.35Å IHH 2008-12-09
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 5H0H_A 100 0 1.72Å OOV 2017-10-04
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 2OFU_A 76.92 2.0E-128 2Å 1N9 2007-02-27
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 1YI6_B 69.37 7.0E-116 2Å - 2006-05-02
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 2BDJ_A 69.49 1.0E-116 2.5Å HET 2006-10-24
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS5_A 100 0 2.85Å VSG 2013-05-01
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) Src (P05480) - MOUSE 6F3F_A 63.35 0 2.41Å ADP 2017-12-27
SH3 domain (45%) (view alignment) HCK (P08631) (Q5QGG3) HUMAN 5NUH_D 100 0 2.78Å - 2017-08-16
SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 4XEY_A 45.01 2.0E-92 2.89Å 1N1 2015-04-01
SH3 domain (100%) (view alignment) HCK (P08631) nef (P03407) HUMAN 3RBB_D 100 0 2.35Å - 2011-04-27
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 2OFV_A 76.53 1.0E-129 2Å 242 2007-02-27
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2HWP_A 69.12 7.0E-116 2.47Å DJK 2007-02-27
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 4K11_A 62.9 0 2.3Å 0J9 2014-04-09
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4DGG_A 69.49 2.0E-116 2.65Å I76 2012-10-10
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3EN4_B 69.49 2.0E-116 2.55Å KS1 2008-10-14
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2QI8_B 68.75 3.0E-115 2.32Å - 2008-03-18
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS1_B 100 0 2.46Å VSA 2013-05-01
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 1QPC_A 76.7 1.0E-130 1.6Å ANP 2000-05-24
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) Btk (P35991) - MOUSE 4XI2_A 38.64 9.0E-89 2.6Å - 2015-02-25
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4LGH_A 69.12 2.0E-115 2.84Å 0JN 2013-08-07
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 2C0O_B 100 0 2.85Å L2G 2006-09-20
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS3_A 100 0 2.17Å VSE 2013-05-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3U51_B 69.26 6.0E-115 2.24Å 08X 2012-02-22
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3AC8_A 76.41 0 2.3Å KSK 2010-06-30
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS4_B 100 0 2.747Å VSF 2013-05-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5D10_B 68.75 3.0E-115 2.7Å 563 2015-09-02
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 4U5J_A 69.49 2.0E-116 2.26Å RXT 2014-09-17
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3UQF_A 69.49 2.0E-116 2.27Å BK5 2012-03-14
SH3 domain (100%) (view alignment) HCK (P08631) nef (P03407) HUMAN 3REB_B 100 0 3.45Å - 2011-06-01
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 1QPD_A 76.34 2.0E-129 2Å STU 2000-05-24
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3EN4_A 69.49 2.0E-116 2.55Å KS1 2008-10-14
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS6_A 100 0 2.37Å VSH 2013-05-01
SH3 domain (100%), SH2 domain (100%) (view alignment) HCK (P08631) - HUMAN 3NHN_A 100 0 2.61Å - 2010-09-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4LGG_A 68.3 8.0E-111 2.4Å VGG 2013-08-07
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3TZ9_B 69.12 7.0E-116 3.1Å AQU 2012-10-10
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5D12_A 68.75 3.0E-115 3Å G97 2015-09-09
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 4MXX_B 69.12 3.0E-116 2.6Å DB8 2013-12-04
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 1YOL_B 69.85 1.0E-116 2.3Å S03 2006-01-27
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3EN7_B 69.49 2.0E-116 2.8Å - 2008-10-14
Protein tyrosine kinase (100%) (view alignment) Lyn (P25911) - MOUSE 2ZV9_A 83.21 0 2.76Å PP2 2008-11-11
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3OEZ_B 69.12 5.0E-116 2.4Å STI 2011-08-17
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3AC3_A 76.41 0 2.55Å KSH 2010-06-30
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2PTK_A 63.35 0 2.35Å - 1997-12-24
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 4MXX_A 69.12 3.0E-116 2.6Å DB8 2013-12-04
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5XP5_B 69.49 2.0E-116 2.07Å 8BU 2018-02-07
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 5H0B_A 100 0 1.65Å OOQ 2017-10-11
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3GEQ_A 69.12 2.0E-115 2.2Å PP2 2009-04-28
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3TZ7_A 69.12 7.0E-116 3.3Å AQB 2012-10-10
Protein tyrosine kinase (100%) (view alignment) Lyn (P25911) - MOUSE 2ZV7_A 83.21 0 2.5Å - 2008-11-11
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3U51_A 69.26 6.0E-115 2.24Å 08X 2012-02-22
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3F3W_B 68.75 3.0E-115 2.6Å 1BU 2009-06-02
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS3_B 100 0 2.17Å VSE 2013-05-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 4YBJ_B 69.49 2.0E-116 2.61Å 4A9 2016-03-02
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 4LUE_B 100 0 3.04Å VSE 2014-02-12
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5XP7_B 69.49 2.0E-116 2Å 8C6 2017-09-06
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3AC4_A 76.41 0 2.7Å KZL 2010-06-30
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 2OIQ_A 69.49 2.0E-116 2Å STI 2007-03-20
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3F3U_A 69.12 7.0E-116 2.5Å 1AW 2009-03-03
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 1Y57_A 63.12 0 1.9Å MPZ 2005-06-21
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3BYS_A 76.45 2.0E-129 2.2Å AM5 2008-09-16
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3DQW_D 69.12 1.0E-115 2.01Å AGS 2008-09-23
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 5H0E_A 100 0 2.1Å OOS 2017-10-04
SH2 domain (100%) (view alignment) HCK (P08631) - HUMAN 3HCK_A 100 0 - 1997-10-15
SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 4XEY_B 45.01 2.0E-92 2.89Å 1N1 2015-04-01
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 2ZYB_A 76.41 0 2.55Å KSL 2009-02-03
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 4MXO_B 69.49 1.0E-116 2.1Å DB8 2013-12-04
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3AD4_A 76.41 0 2.2Å KBM 2011-01-19
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 1OPL_A 39.85 6.0E-102 3.4Å P16 2003-04-08
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 1YOM_B 69.49 4.0E-116 2.7Å P01 2006-01-27
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS7_B 100 0 2.95Å KS1 2013-05-01
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3ACJ_A 76.41 0 2.2Å KSS 2010-06-30
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4FIC_A 69.49 2.0E-116 2.5Å 0UL 2013-04-10
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4DGG_B 69.49 2.0E-116 2.65Å I76 2012-10-10
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3F3T_A 69.12 7.0E-116 2.5Å 1AU 2009-03-03
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5BMM_B 69.49 2.0E-116 2.5Å - 2016-09-21
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 5H09_A 100 0 1.95Å OOO 2017-10-04
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5XP5_A 69.49 2.0E-116 2.07Å 8BU 2018-02-07
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3F6X_C 69.49 2.0E-116 2.35Å IHH 2008-12-09
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3SVV_A 69.12 1.0E-115 2.2Å VSP 2011-08-17
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3G6H_B 69.12 1.0E-115 2.35Å G6H 2009-03-24
SH3 domain (100%) (view alignment) HCK (P08631) - HUMAN 5HCK_A 100 0 - 1998-06-17
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 2C0O_A 100 0 2.85Å L2G 2006-09-20
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) CSK (P41240) CHICKEN 3D7T_B 69.49 2.0E-116 2.89Å STU 2008-08-05
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 1KSW_A 62.9 0 2.8Å NBS 2002-02-27
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS1_A 100 0 2.46Å VSA 2013-05-01
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4MCV_A 69.12 2.0E-115 2.73Å 29K 2013-11-20
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5D10_A 68.75 3.0E-115 2.7Å 563 2015-09-02
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3AC5_A 76.41 0 2.5Å KZM 2010-06-30
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS0_B 100 0 2.93Å VS0 2013-05-01
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 2C0I_A 100 0 2.3Å L1G 2006-09-20
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3EL8_A 69.49 2.0E-116 2.3Å PD5 2008-10-28
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) CSK (P41240) CHICKEN 3D7U_B 69.49 4.0E-116 4.012Å - 2008-08-05
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 2BDF_B 69.49 1.0E-116 2.1Å 24A 2006-10-24
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 2OG8_A 76.98 2.0E-124 2.3Å 1N8 2007-02-27
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 3VS2_A 100 0 2.609Å VSB 2013-05-01
SH3 domain (100%) (view alignment) HCK (P08631) nef (P03407) HUMAN 3REB_D 100 0 3.45Å - 2011-06-01
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 2OF2_A 76.75 5.0E-127 2Å 547 2007-02-27
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5D11_B 68.75 3.0E-115 2.3Å 56G 2015-09-09
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) Csk (P32577) - NORWAY RAT 1K9A_D 37.89 1.0E-79 2.5Å - 2002-03-20
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3EN6_A 69.49 2.0E-116 2.39Å - 2008-10-14
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3F3U_B 69.12 7.0E-116 2.5Å 1AW 2009-03-03
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3UQG_B 69.49 2.0E-116 2.2Å B5A 2012-03-14
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3AC2_A 76.41 0 2.1Å KSE 2010-06-30
Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 5ZJ6_A 100 0 1.696Å VSE 2018-06-06
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3DQX_A 69.49 2.0E-116 2.3Å AMP 2008-09-23
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 2OFV_B 76.53 1.0E-129 2Å 242 2007-02-27
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) HCK (P08631) - HUMAN 4LUE_A 100 0 3.04Å VSE 2014-02-12
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3GEQ_B 69.12 2.0E-115 2.2Å PP2 2009-04-28
SH3 domain (100%), SH2 domain (100%), Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 1OPK_A 43.92 2.0E-101 1.8Å P16 2003-04-08
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 5SYS_A 69.12 8.0E-116 2.8Å 72F 2017-08-16
SH3 domain (100%) (view alignment) HCK (P08631) - HUMAN 1BU1_D 100 0 2.6Å - 1998-11-11
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 4LGG_B 68.3 8.0E-111 2.4Å VGG 2013-08-07
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3AC1_A 76.41 0 1.99Å KZI 2010-06-30
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3BYM_A 76.84 9.0E-128 2Å AM0 2008-09-16
SH3 domain (100%), SH2 domain (100%) (view alignment) HCK (P08631) nef (P03407) HUMAN 4U5W_D 100 0 1.86Å - 2014-08-20
Protein tyrosine kinase (100%) (view alignment) SRC (P12931) - HUMAN 1YOJ_A 69.49 4.0E-116 1.95Å - 2006-01-27
Protein tyrosine kinase (100%) (view alignment) LCK (P06239) - HUMAN 3AD6_A 76.41 0 2.15Å KSC 2011-01-19
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - CHICKEN 3G6G_A 69.49 2.0E-116 2.3Å G6G 2009-03-24
Protein tyrosine kinase (100%) (view alignment) SRC (P00523) - BANTAM,CHICKENS 3EN5_B 69.49 2.0E-116 2.65Å KS4 2008-10-14
Protein tyrosine kinase (100%) (view alignment) - 4UEU_A 60 2.0E-93 2.95Å ACP 2015-02-18
Protein tyrosine kinase (100%) (view alignment) LYN (P07948) - HUMAN 5XY1_A 82.48 0 2.7Å 8H0 2017-08-02